[Amino(4-chlorophenyl)methyl]phosphonic acid

Base Information

Chemical Name:[Amino(4-chlorophenyl)methyl]phosphonic acid
CAS No.:16656-60-3
Molecular Formula:C7H9ClNO3P
Molecular Weight:221.58
Hs Code.:
DSSTox Substance ID:DTXSID50508187
Nikkaji Number:J1.508.223B

Synonyms:16656-60-3;SCHEMBL11497064;DTXSID50508187;amino(4-chlorophenyl)methylphosphonic acid;[Amino(4-chlorophenyl)methyl]phosphonic acid;[amino-(4-chlorophenyl)-methyl]-phosphonic acid

Suppliers and Price of [Amino(4-chlorophenyl)methyl]phosphonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [Amino(4-chlorophenyl)methyl]phosphonic acid

Chemical Property:

XLogP3:-2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:221.0008578
Heavy Atom Count:13
Complexity:212

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(N)P(=O)(O)O)Cl

Technology Process of [Amino(4-chlorophenyl)methyl]phosphonic acid

There total 8 articles about [Amino(4-chlorophenyl)methyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 104-88-1
4-chlorobenzaldehyde

: 16656-60-3
[amino-(4-chlorophenyl)methyl]phosphonic acid

Guidance literature:: 4-chlorobenzaldehyde; With acetamide; acetic acid; acetyl chloride; In neat (no solvent); at 20 ℃; for 24h;

With phosphorus trichloride; In neat (no solvent); at 0 - 80 ℃;
DOI:10.1016/j.biochi.2018.06.005

Reference yield:

: [(Benzhydryl-amino)-(4-chloro-phenyl)-methyl]-phosphonic acid dimethyl ester

: 16656-60-3
[amino-(4-chlorophenyl)methyl]phosphonic acid

: 90-99-3
diphenylchloromethane

Guidance literature:: With hydrogenchloride; for 3h; Yield given; Heating;
DOI:10.1016/S0040-4020(01)90420-X

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 16656-60-3
[amino-(4-chlorophenyl)methyl]phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 3 h / 20 °C

2: 4 h / 100 °C

3: aq. HCl / 4 h / Heating

With hydrogenchloride; In dichloromethane;
DOI:10.1016/S0031-9422(01)00425-3