(4-bromophenoxy)acetyl chloride

Base Information

• Chemical Name: (4-bromophenoxy)acetyl chloride
• CAS No.: 16738-06-0
• Molecular Formula: C8H6BrClO2
• Molecular Weight: 249.491
• Hs Code.: 2918990090
• Mol file: 16738-06-0.mol

Synonyms:(4-bromo-phenoxy)-acetic acid amide;Acetamide,2-(4-bromophenoxy);4-bromophenoxyacetyl chloride;4-Brom-phenoxyessigsaeure-chlorid;(4-Brom-phenoxy)-essigsaeure-amid;2-(4-Bromo-phenoxy)-acetamide;<4-Brom-phenoxy>-acetylchlorid;

Chemical Property of (4-bromophenoxy)acetyl chloride

Chemical Property:

• Boiling Point: 154 °C(Press: 12 Torr)
• PSA: 26.30000
• Density: 1.613±0.06 g/cm3(Predicted)
• LogP: 2.59330

Purity/Quality:

98%min ^*data from raw suppliers

(4-Bromophenoxy)acetyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-bromophenoxy)acetyl chloride

There total 5 articles about (4-bromophenoxy)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-bromophenoxy)acetic acid (1878-91-7) → 4-bromophenoxyacetyl chloride (16738-06-0)

Guidance literature:

With phosphorus pentachloride; man destilliert das Reaktionsprodukt unter vermindertem Druck;

Reference yield:

4-bromo-phenol (106-41-2) + chloroacetic acid (79-11-8) → 4-bromophenoxyacetyl chloride (16738-06-0)

Guidance literature:

4-bromo-phenol; chloroacetic acid; With sodium hydroxide; In water; for 3h; Reflux;

With thionyl chloride; In toluene; for 1h; Reflux;

DOI:10.1016/j.bioorg.2018.03.019

Reference yield:

4-bromo-phenol (106-41-2) → 4-bromophenoxyacetyl chloride (16738-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / 1 h / Heating

2: SOCl₂ / 8 h / Heating

With sodium hydroxide; thionyl chloride;

upstream raw materials:

(4-bromophenoxy)acetic acid

4-bromo-phenol

ethyl 2-(4-bromophenoxy)acetate

chloroacetic acid

Downstream raw materials:

2-<4-Brom-phenoxy>-peressigsaeure-tert.-butylester

1-Aziridin-1-yl-2-(4-bromo-phenoxy)-ethanone

2-(4-Bromo-phenoxy)-1-(4-methyl-piperazin-1-yl)-ethanone

(4-Bromo-phenoxy)-acetic acid 2,2-dibromo-vinyl ester

Refernces

• 1、 Patel, Shivani,Modi, Palmi,Ranjan, Vishal,Chhabria, Mahesh. "Structure-based design, synthesis and evaluation of 2,4-diaminopyrimidine derivatives as novel caspase-1 inhibitors". . p. 258 - 268. Retrieved 2018/04/05.
• 2、 Ferreira, Rafaela S.,Dessoy, Marco A.,Pauli, Ivani,Souza, Mariana L.,Krogh, Renata,Sales, Ana I. L.,Oliva, Glaucius,Dias, Luiz C.,Andricopulo, Adriano D.. "Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents". supporting information. p. 2380 - 2392. Retrieved 2014/04/17.