Cyclohexanone, 3-(2-phenylethyl)-, (R)-

Base Information

Chemical Name:Cyclohexanone, 3-(2-phenylethyl)-, (R)-
CAS No.:168038-38-8
Molecular Formula:C14H18O
Molecular Weight:202.296
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanone, 3-(2-phenylethyl)-, (R)-

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Technology Process of Cyclohexanone, 3-(2-phenylethyl)-, (R)-

There total 7 articles about Cyclohexanone, 3-(2-phenylethyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 930-68-7
cyclohexenone

: 90878-19-6
phenethylmagnesium chloride

: 168038-38-8
(R)-(-)-3-(2-phenylethyl)cyclohexanone

Guidance literature:: phenethylmagnesium chloride; With Zn(OMe)2; In diethyl ether; at 20 ℃; for 1h;

cyclohexenone; (R)-binaphthol-(S,S)-chiral phosphoramidite; In diethyl ether; toluene; at -30 ℃; for 20h; Further stages.;
DOI:10.1021/ja710864p

Reference yield: 97.0%

: 930-68-7
cyclohexenone

: 74685-32-8
diphenethylzinc

: 168038-38-8
(R)-(-)-3-(2-phenylethyl)cyclohexanone

Guidance literature:: (Ra,S(C),S(C))-O,O'-[1,1'-binaphthyl-2,2'-diyl]-N,N-bis[1-phenylethyl]phosphoramidite; copper(II) bis(trifluoromethanesulfonate); In diethyl ether; toluene; at -30 ℃; for 20h; Product distribution / selectivity;

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 168038-38-8
(R)-(-)-3-(2-phenylethyl)cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / tetrahydrofuran / 15 h / 60 °C

1.2: 91 percent / tetrahydrofuran / 34 h / 20 °C

2.1: 99 percent / Hantzsch ester / valine tert-butyl ester (R)-TRIP salt / dibutyl ether / 48 h / 60 °C

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; magnesium; valine tert-butyl ester (R)-TRIP salt; In tetrahydrofuran; dibutyl ether;
DOI:10.1021/ja065708d