4-Thiazolecarboxylic acid, 2-[2-(1H-indol-3-yl)-1-[[(phenylmethoxy)carbonyl]amino]ethyl]-5-methyl-, ethyl ester, (R)-

Base Information

Chemical Name:4-Thiazolecarboxylic acid, 2-[2-(1H-indol-3-yl)-1-[[(phenylmethoxy)carbonyl]amino]ethyl]-5-methyl-, ethyl ester, (R)-
CAS No.:168470-73-3
Molecular Formula:C25H25N3O4S
Molecular Weight:463.557
Hs Code.:
Mol file:168470-73-3.mol

Synonyms:

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Chemical Property of 4-Thiazolecarboxylic acid, 2-[2-(1H-indol-3-yl)-1-[[(phenylmethoxy)carbonyl]amino]ethyl]-5-methyl-, ethyl ester, (R)-

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Technology Process of 4-Thiazolecarboxylic acid, 2-[2-(1H-indol-3-yl)-1-[[(phenylmethoxy)carbonyl]amino]ethyl]-5-methyl-, ethyl ester, (R)-

There total 4 articles about 4-Thiazolecarboxylic acid, 2-[2-(1H-indol-3-yl)-1-[[(phenylmethoxy)carbonyl]amino]ethyl]-5-methyl-, ethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 168470-53-9
2-[(R)-2-Benzyloxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-oxo-butyric acid ethyl ester

: 168470-73-3
2-[(R)-1-Benzyloxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; for 5h; Heating;
DOI:10.1021/jm950591h

Reference yield:

: 20207-16-3
ethyl 2-amino-3-oxobutanoate hydrochloride

: 168470-73-3
2-[(R)-1-Benzyloxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

2: 46 percent / Lawesson's reagent / tetrahydrofuran / 5 h / Heating

With Lawessons reagent; 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm950591h

Reference yield:

: 133641-28-8
C₂₄H₂₆N₂O₆

: 168470-73-3
2-[(R)-1-Benzyloxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-5-methyl-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

2: 46 percent / Lawesson's reagent / tetrahydrofuran / 5 h / Heating

With Lawessons reagent; 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm950591h