2-PhenylpyriMidine-4-carboxylic acid

Base Information

• Chemical Name: 2-PhenylpyriMidine-4-carboxylic acid
• CAS No.: 16879-53-1
• Molecular Formula: C11H8N2O2
• Molecular Weight: 200.197
• Hs Code.: 2933599090
• Mol file: 16879-53-1.mol

Synonyms:4-Pyrimidinecarboxylic acid,2-phenyl;2-phenyl-4-pyrimidinecarboxylic acid;2-phenyl-pyrimidine-4-carboxylic acid;2-Phenyl-pyrimidin-carbonsaeure-(4);2-Phenylpyrimidin-4-carbonsaeure;

Chemical Property of 2-PhenylpyriMidine-4-carboxylic acid

Chemical Property:

• PSA: 63.08000
• LogP: 1.84180
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Phenylpyrimidine-4-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-PhenylpyriMidine-4-carboxylic acid

There total 3 articles about 2-PhenylpyriMidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

pyruvic acid methyl ester (600-22-6) + benzamidine monohydrochloride (1670-14-0) → 2-phenylpyrimidine-4-carboxylic acid (16879-53-1)

Guidance literature:

pyruvic acid methyl ester; N,N-dimethyl-formamide dimethyl acetal; at 80 ℃; for 2h;

benzamidine monohydrochloride; With sodium methylate; In methanol; for 3h; Heating / reflux;

Reference yield:

5-bromo-2-phenyl-pyrimidine-4-carboxylic acid (179260-95-8) → 2-phenylpyrimidine-4-carboxylic acid (16879-53-1)

Guidance literature:

With H₂; N-ethyl-N,N-diisopropylamine; palladium; In ethanol; water;

Reference yield:

→ 2-phenylpyrimidine-4-carboxylic acid (16879-53-1)

Guidance literature:

2-Phenyl-4-methyl-pyrimidin (IIIe), SeO2, Py., Δ;

DOI:10.1248/yakushi1947.90.7_877

upstream raw materials:

5-bromo-2-phenyl-pyrimidine-4-carboxylic acid

pyruvic acid methyl ester

benzamidine monohydrochloride

Downstream raw materials:

2-phenyl-4-pyrimidinecarboxylic acid chloride