N-Thiazol-2-yl-succinamic acid

Base Information

• Chemical Name: N-Thiazol-2-yl-succinamic acid
• CAS No.: 19692-00-3
• Molecular Formula: C7H8 N2 O3 S
• Molecular Weight: 200.21
• Hs Code.: 2934100090
• NSC Number: 80809
• DSSTox Substance ID: DTXSID60292202
• Nikkaji Number: J3.543.455K
• Wikidata: Q82030413
• Mol file: 19692-00-3.mol

Synonyms:19692-00-3;N-Thiazol-2-yl-succinamic acid;n-thiazol-2-ylsuccinamic acid;4-oxo-4-(1,3-thiazol-2-ylamino)butanoic acid;3-[(1,3-thiazol-2-yl)carbamoyl]propanoic acid;4-oxo-4-(thiazol-2-ylamino)butanoic acid;3-(1,3-thiazol-2-ylcarbamoyl)propanoic acid;Butanoicacid, 4-oxo-4-(2-thiazolylamino)-;NSC80809;Oprea1_057043;Oprea1_497240;Oprea1_526854;3-(N-(1,3-thiazol-2-yl)carbamoyl)propanoic acid;IFLab1_000192;SCHEMBL6252743;n-(2-thiazolyl) succinamic acid;DTXSID60292202;HMS1412I16;HMS1769A01;CCG-40389;NSC-80809;STK293181;AKOS000300976;AKOS003616095;N-(2-THIAZOLYL)SUCCINAMIC ACID;SDCCGMLS-0065441.P001;IDI1_008411;4-oxo-4-(thiazol-2-ylamino)butanoicacid;Butanoicacid,4-oxo-4-(2-thiazolylamino)-;CS-0248031;EN300-38853;SR-01000313675;J-012730;SR-01000313675-1;Z56759043;F0017-0486;4-oxo-4-[(2E)-1,3-thiazol-2(3H)-ylideneamino]butanoic acid

Chemical Property of N-Thiazol-2-yl-succinamic acid

Chemical Property:

• Vapor Pressure: 3.88E-08mmHg at 25°C
• Boiling Point: 417.4°Cat760mmHg
• PKA: 4.40±0.10(Predicted)
• Flash Point: 206.3°C
• PSA: 107.53000
• Density: 1.507g/cm³
• LogP: 1.01940
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 200.02556330
• Heavy Atom Count: 13
• Complexity: 210

Purity/Quality:

98%min ^*data from raw suppliers

3-[(1,3-thiazol-2-yl)carbamoyl]propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=N1)NC(=O)CCC(=O)O

Technology Process of N-Thiazol-2-yl-succinamic acid

There total 3 articles about N-Thiazol-2-yl-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-thiazolylamine (96-50-4) + succinic acid anhydride (108-30-5) → 4-(thiazol-2-ylamino)-4-oxobutanoic acid (19692-00-3)

Guidance literature:

In acetone; for 4h; Heating;

DOI:10.1007/BF02223742

Reference yield: 90.0%

4-(thiazole-2-ylamino)-4-oxo-butyric acid methyl ester (329205-47-2) → 4-(thiazol-2-ylamino)-4-oxobutanoic acid (19692-00-3)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.bmcl.2007.01.053

Reference yield:

→ 4-(thiazol-2-ylamino)-4-oxobutanoic acid (19692-00-3)

Guidance literature:

upstream raw materials:

2-thiazolylamine

succinic acid anhydride

4-(thiazole-2-ylamino)-4-oxo-butyric acid methyl ester

Downstream raw materials:

4-(thiazole-2-ylamino)-4-oxo-butyric acid methyl ester