2-[(2,4-difluorophenoxy)methyl]oxirane

Base Information

• Chemical Name: 2-[(2,4-difluorophenoxy)methyl]oxirane
• CAS No.: 169286-61-7
• Molecular Formula: C9H8F2O2
• Molecular Weight: 0.00000
• Hs Code.: 2910900090
• Mol file: 169286-61-7.mol

Synonyms:

Chemical Property of 2-[(2,4-difluorophenoxy)methyl]oxirane

Chemical Property:

• Boiling Point: 254.7±20.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.309±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

97% ^*data from raw suppliers

2-[(2,4-Difluorophenoxy)methyl]oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2,4-difluorophenoxy)methyl]oxirane

There total 1 articles about 2-[(2,4-difluorophenoxy)methyl]oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,4-difluorophenol (367-27-1) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(2,3-epoxypropoxy)-2,4-difluorobenzene (169286-61-7)

Guidance literature:

With sodium hydroxide; In methanol; for 6h; Heating;

DOI:10.1248/cpb.43.1045

Reference yield:

1-(2,3-epoxypropoxy)-2,4-difluorobenzene (169286-61-7) → (4-{2-[3-(2,4-Difluoro-phenoxy)-2-hydroxy-propylamino]-ethoxy}-phenoxy)-acetic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: propan-2-ol / 72 h / Heating

2: K₂CO₃, KI / acetone / 24 h / Heating

3: H₂, AcOH / 10percent Pd/C / methanol / 48 h / 60 °C / 15001.2 Torr

With hydrogen; potassium carbonate; acetic acid; potassium iodide; palladium on activated charcoal; In methanol; isopropyl alcohol; acetone;

DOI:10.1021/jm00088a010

Reference yield:

1-(2,3-epoxypropoxy)-2,4-difluorobenzene (169286-61-7) → [4-(2-{Benzyl-[3-(2,4-difluoro-phenoxy)-2-hydroxy-propyl]-amino}-ethoxy)-phenoxy]-acetic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol / 72 h / Heating

2: K₂CO₃, KI / acetone / 24 h / Heating

With potassium carbonate; potassium iodide; In isopropyl alcohol; acetone;

DOI:10.1021/jm00088a010

upstream raw materials:

2,4-difluorophenol

epichlorohydrin

Refernces