Thiophene, 2-methyl-4-phenyl-

Base Information

• Chemical Name: Thiophene, 2-methyl-4-phenyl-
• CAS No.: 16939-14-3
• Molecular Formula: C11H10S
• Molecular Weight: 174.266
• Mol file: 16939-14-3.mol

Synonyms:

Chemical Property of Thiophene, 2-methyl-4-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophene, 2-methyl-4-phenyl-

There total 12 articles about Thiophene, 2-methyl-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-Methylthiophene (554-14-3) + benzenesulfonyl chloride (98-09-9) → 2-methyl-4-phenylthiophene (16939-14-3)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); lithium carbonate; In 1,4-dioxane; at 140 ℃; for 40h; regioselective reaction; Schlenk technique;

DOI:10.1039/c3sc52420e

Reference yield: 76.0%

2-Methylthiophene (554-14-3) + iodobenzene (591-50-4) → 2-methyl-4-phenylthiophene (16939-14-3)

Guidance literature:

With C₄₁H₃₆N₂O₅P₂Pd₂; silver carbonate; In toluene; at 120 ℃; for 15h; regioselective reaction;

DOI:10.1002/cctc.201501132

Reference yield: 65.0%

2-Methylthiophene (554-14-3) + phenylboronic acid (98-80-6) → 2-methyl-4-phenylthiophene (16939-14-3)

Guidance literature:

With [2,2]bipyridinyl; 2,2,6,6-tetramethyl-piperidine-N-oxyl; palladium diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201007060

upstream raw materials:

(E/Z)-2-phenylpent-2-ene

4-bromo-2-methylthiophene

2-Methylthiophene

phenylboronic acid