N-[[(4-Methoxyphenyl)methoxy]carbonyl]-L-alanine

Base Information

• Chemical Name: N-[[(4-Methoxyphenyl)methoxy]carbonyl]-L-alanine
• CAS No.: 16944-75-5
• Molecular Formula: C12H15NO5
• Molecular Weight: 253.255
• DSSTox Substance ID: DTXSID901239019
• Mol file: 16944-75-5.mol

Synonyms:N-[[(4-Methoxyphenyl)methoxy]carbonyl]-L-alanine;SCHEMBL11816446;DTXSID901239019;16944-75-5

Chemical Property of N-[[(4-Methoxyphenyl)methoxy]carbonyl]-L-alanine

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 253.09502258
• Heavy Atom Count: 18
• Complexity: 286

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(=O)O)NC(=O)OCC1=CC=C(C=C1)OC
• Isomeric SMILES: C[C@@H](C(=O)O)NC(=O)OCC1=CC=C(C=C1)OC

Technology Process of N-[[(4-Methoxyphenyl)methoxy]carbonyl]-L-alanine

There total 8 articles about N-[[(4-Methoxyphenyl)methoxy]carbonyl]-L-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-alanin (56-41-7,25191-17-7,18875-37-1) + 4-methoxybenzyloxycarbonyl azide (25474-85-5) → (S)-2-(4-Methoxy-benzyloxycarbonylamino)-propionic acid (16944-75-5)

Guidance literature:

With magnesium oxide; In 1,4-dioxane; water;

Reference yield:

4-Methoxybenzyl alcohol (105-13-5) → (S)-2-(4-Methoxy-benzyloxycarbonylamino)-propionic acid (16944-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) Et₂O, (ii) /BRN= 1285380/, Et₃N

2: aq. Et₃N / dioxane

With triethylamine; In 1,4-dioxane;

Reference yield:

L-alanin (56-41-7,25191-17-7,18875-37-1) + <4-Methoxy-benzyl>-pentachlorphenyl-carbonat (18912-36-2) → (S)-2-(4-Methoxy-benzyloxycarbonylamino)-propionic acid (16944-75-5)

Guidance literature:

With triethylamine; In 1,4-dioxane;

upstream raw materials:

L-alanin

4-methoxybenzyloxycarbonyl azide

phosgene

4-Methoxybenzyl alcohol

Downstream raw materials:

Z(OMe)-Ala-Tht

Z(OMe)-Ala-Ser-OMe

Z(OMe)-Ala-Thr-OMe

Z(OMe)-Ala-Phe-OBzl