Technology Process of 3,6-Difluorobenzo(h)quinoline
There total 4 articles about 3,6-Difluorobenzo(h)quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2percent aq. HCl / 0.5 h / 50 °C
2: 29 percent / ZnCl2 / N,N-dimethyl-acetamide / 2.5 h / 180 °C
3: 100 percent / H2 / 5percent Pd-C / ethanol
4: 1.) isoamyl nitrite, 42percent HBF4 / 1.) EtOH, 0 deg C, 2.) xylene, reflux, 1 h
With
hydrogenchloride; tetrafluoroboric acid; hydrogen; zinc(II) chloride; isopentyl nitrite;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl acetamide;
DOI:10.1248/cpb.44.2254
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / H2 / 5percent Pd-C / ethanol
2: 1.) isoamyl nitrite, 42percent HBF4 / 1.) EtOH, 0 deg C, 2.) xylene, reflux, 1 h
With
tetrafluoroboric acid; hydrogen; isopentyl nitrite;
palladium on activated charcoal;
In
ethanol;
DOI:10.1248/cpb.44.2254
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 29 percent / ZnCl2 / N,N-dimethyl-acetamide / 2.5 h / 180 °C
2: 100 percent / H2 / 5percent Pd-C / ethanol
3: 1.) isoamyl nitrite, 42percent HBF4 / 1.) EtOH, 0 deg C, 2.) xylene, reflux, 1 h
With
tetrafluoroboric acid; hydrogen; zinc(II) chloride; isopentyl nitrite;
palladium on activated charcoal;
In
ethanol; N,N-dimethyl acetamide;
DOI:10.1248/cpb.44.2254