4-Fluoro-1-naphthylamine

Base Information

• Chemical Name: 4-Fluoro-1-naphthylamine
• CAS No.: 438-32-4
• Molecular Formula: C10H8FN
• Molecular Weight: 161.179
• Hs Code.: 2921450090
• Mol file: 438-32-4.mol

Synonyms:1-Naphthylamine,4-fluoro- (6CI,8CI);1-Amino-4-fluoronaphthalene;4-Fluoro-1-naphthylamine;

Chemical Property of 4-Fluoro-1-naphthylamine

Chemical Property:

• Vapor Pressure: 0.000626mmHg at 25°C
• Melting Point: 48 °C
• Refractive Index: 1.665
• Boiling Point: 309.8 °C at 760 mmHg
• PKA: 3.20±0.10(Predicted)
• Flash Point: 153.2 °C
• PSA: 26.02000
• Density: 1.239 g/cm³
• LogP: 3.14230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

4-Fluoronaphthalen-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Fluoro-1-naphthylamine

There total 12 articles about 4-Fluoro-1-naphthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-boc-1-amino-4-fluoronaphthalene → 4-Fluoro-1-aminonaphthalene (438-32-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1124/mol.113.087502

Reference yield: 53.0%

(4-fluoronaphthalen-1-yl)magnesium bromide (17318-06-8) → 4-Fluoro-1-aminonaphthalene (438-32-4)

Guidance literature:

(4-fluoronaphthalen-1-yl)magnesium bromide; With copper(I) chloride bis(lithium chloride) complex; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

With 3,3’-di-tert-butyl oxaziridine; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/jacs.6b12712

Reference yield: 31.0%

1-bromo-4-fluoronaphthalene (341-41-3) → 4-Fluoro-1-aminonaphthalene (438-32-4)

Guidance literature:

1-bromo-4-fluoronaphthalene; With magnesium; In tetrahydrofuran; Inert atmosphere;

With C₁₀H₁₇NO; In tetrahydrofuran; toluene; at -45 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; toluene; Inert atmosphere;

DOI:10.1038/nchem.2672

upstream raw materials:

1-fluoro-4-nitronaphthalene

N-(4-fluoro-[1]naphthyl)-acetamide

hydrogenchloride

sulfuric acid

Downstream raw materials:

N-(4-chloro-phenyl)-N'-(4-fluoro-[1]naphthyl)-urea

1-iodo-4-fluoronaphthalene

1-chloro-4-fluoro-naphthalene

3-bromo-1-fluoronaphthalene

Refernces

• 1、 -. "AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS". Paragraph 0098; 0134; 0135; 0149; 0257. . Retrieved 2018/03/25.
• 2、 Gao, Hongyin,Zhou, Zhe,Kwon, Doo-Hyun,Coombs, James,Jones, Steven,Behnke, Nicole Erin,Ess, Daniel H.,Kürti, László. "Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds". . p. 681 - 688. Retrieved 2017/06/30.