4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Base Information

Chemical Name:4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
CAS No.:170569-86-5
Molecular Formula:C16H11ClF3N3O2S
Molecular Weight:401.796
Hs Code.:2935009090
European Community (EC) Number:687-421-9
UNII:9HGW1H8S2M
DSSTox Substance ID:DTXSID80432082
Nikkaji Number:J881.718I
Wikidata:Q82246144
Pharos Ligand ID:DGP1JPRQ3NSK
Metabolomics Workbench ID:154764
ChEMBL ID:CHEMBL282093
Mol file:170569-86-5.mol

Synonyms:4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide;SC 236;SC 58236;SC-236;SC-58236;SC236;SC58236

Suppliers and Price of 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SC-58236
25mg
$ 446.00

Tocris
SC236 ≥99%(HPLC)
10
$ 179.00

Sigma-Aldrich
SC-236 ≥98% (HPLC)
5mg
$ 109.00

Sigma-Aldrich
SC-236 ≥98% (HPLC)
25mg
$ 423.00

DC Chemicals
SC-236 >98%
100 mg
$ 550.00

CSNpharm
SC236
10mg
$ 65.00

CSNpharm
SC236
5mg
$ 40.00

CSNpharm
SC236
1mg
$ 25.00

CSNpharm
SC236
100mg
$ 300.00

CSNpharm
SC236
50mg
$ 180.00

Total 10 raw suppliers

Chemical Property of 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Chemical Property:

Melting Point:146-148°C
Boiling Point:543.4±60.0 °C(Predicted)
PKA:9.66±0.10(Predicted)
PSA：86.36000
Density:1.54±0.1 g/cm3(Predicted)
LogP:5.64000
Storage Temp.:Store at RT
Solubility.:DMSO: >20mg/mL
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:401.0212600
Heavy Atom Count:26
Complexity:583

Purity/Quality:

99%, ^*data from raw suppliers

SC-58236 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)Cl
Uses 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE is a highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory ef fects allows for potential use in therapy for inflammatory allergic diseases. SC-236 has been used as a COX-2 inhibitor to study its effects on the mechano-reflex in rats.

Technology Process of 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

There total 7 articles about 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%