METHYL 1-[4-(AMINOSULFONYL)PHENYL]-5-(4-CHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1-[4-(AMINOSULFONYL)PHENYL]-5-(4-CHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE
• CAS No.: 170571-20-7
• Molecular Formula: C17H14ClN3O4S
• Molecular Weight: 391.82900
• Mol file: 170571-20-7.mol

Synonyms:5-(4-Chloro-phenyl)-1-(4-sulfamoyl-phenyl)-1H-pyrazole-3-carboxylic acid methyl ester;methyl 1-(4-aminosulfonylphenyl)-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate;Methyl 5-(4-chlorophenyl)-1-(4-sulfamoylphenyl)pyrazole-3-carboxylate;Methyl [1-(4-aminosulfonylphenyl)-5-(4-chlorophenyl)-1H-pyrazole-3yl]carboxylate;

Chemical Property of METHYL 1-[4-(AMINOSULFONYL)PHENYL]-5-(4-CHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

Chemical Property:

• PSA: 112.66000
• LogP: 4.40780

Purity/Quality:

99% ^*data from raw suppliers

Methyl 1-[4-(aminosulfonyl)phenyl]-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-[4-(AMINOSULFONYL)PHENYL]-5-(4-CHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

There total 6 articles about METHYL 1-[4-(AMINOSULFONYL)PHENYL]-5-(4-CHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) + methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate (39757-35-2) → methyl-1-[4-(aminosulfonyl)phenyl]-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate (170571-20-7)

Guidance literature:

In methanol; for 0.5h; Heating;

DOI:10.1021/jm960803q

Reference yield:

Dimethyl oxalate (553-90-2) + para-chloroacetophenone (99-91-2) + 4-aminosulfonylphenylhydrazine (4392-54-5) → methyl-1-[4-(aminosulfonyl)phenyl]-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate (170571-20-7)

Guidance literature:

Dimethyl oxalate; para-chloroacetophenone; With sodium methylate; In methanol; for 12h; Reflux;

4-aminosulfonylphenylhydrazine; In methanol; at 70 ℃; for 6h;

DOI:10.1016/j.bioorg.2020.104390

Reference yield:

4-sulfonamidylphenyl hydrazine hydrochloride + methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate (39757-35-2) → methyl-1-[4-(aminosulfonyl)phenyl]-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate (170571-20-7)

Guidance literature:

With NH-pyrazole; In methanol;

upstream raw materials:

4-hydrazinobenzene-1-sulfonamide hydrochloride

methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate

para-chloroacetophenone

methyl (p-chlorphenyl)glyoxylate

Downstream raw materials:

1-[4-(aminosulfonyl)phenyl]-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid

methyl [1-(4-aminosulfonylphenyl)-4-chloro-5-(4-chlorophenyl)-1H-pyrazol-3-yl]carboxylate

[1-(4-aminosulfonylphenyl)-4-chloro-5-(4-chlorophenyl)-1H-pyrazol-3-yl]carboxamide

[1-(4-aminosulfonylphenyl)-4-chloro-5-(4-chlorophenyl)-1H-pyrazol-3-yl]carboxylic acid

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