trans-(3R,4S)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone

Base Information

• Chemical Name: trans-(3R,4S)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone
• CAS No.: 129086-49-3
• Molecular Formula: C₂₆H₃₇N₃OSi₂
• Molecular Weight: 463.77
• Mol file: 129086-49-3.mol

Synonyms:

Chemical Property of trans-(3R,4S)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(3R,4S)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone

There total 3 articles about trans-(3R,4S)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane-1-acetate (78605-23-9) + 1,4-bis<(R)-α-methylbenzyl>-1,4-diaza-1,3-butadiene (129171-89-7) → trans-(3S,4R)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone (141040-00-8) + trans-(3R,4S)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone (129086-49-3)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00040a034

Reference yield:

ethyl 2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane-1-acetate (78605-23-9) + 1,4-bis<(R)-α-methylbenzyl>-1,4-diaza-1,3-butadiene (129171-89-7) → trans-(3S,4R)-1-(R)-α-methylbenzyl-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4-N-(R)-α-methylbenzyliminoazetidin-2-one (141040-00-8) + trans-(3R,4S)-1-(R)-α-methylbenzyl-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4-N-(R)-α-methylbenzyliminoazetidin-2-one (129086-49-3)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/C39900000503

Reference yield:

ethyl 2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane-1-acetate (78605-23-9) + 1,4-bis<(R)-α-methylbenzyl>-1,4-diaza-1,3-butadiene (129171-89-7) → trans-(3R,4S)-1(R)-(α-methylbenzyl)-3-(2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentyl)-4--2-azetidinone (129086-49-3)

Guidance literature:

Mechanism; multistep reaction; enantioselective synthesis of 3-amino-2-azetidinones via the ester enolate-imine condensation; other substrates;

DOI:10.1021/jo00040a034

upstream raw materials:

ethyl 2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane-1-acetate

1,4-bis<(R)-α-methylbenzyl>-1,4-diaza-1,3-butadiene