methyl (2E)-2-[(4-methylphenyl)hydrazinylidene]acetate

Base Information

• Chemical Name: methyl (2E)-2-[(4-methylphenyl)hydrazinylidene]acetate
• CAS No.: 90918-13-1
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• NSC Number: 240010
• DSSTox Substance ID: DTXSID90429640
• Mol file: 90918-13-1.mol

Synonyms:NSC240010;90918-13-1;DTXSID90429640;NSC-240010

Chemical Property of methyl (2E)-2-[(4-methylphenyl)hydrazinylidene]acetate

Chemical Property:

• Vapor Pressure: 0.00278mmHg at 25°C
• Boiling Point: 285.6°Cat760mmHg
• Flash Point: 126.5°C
• Density: 1.08g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 192.089877630
• Heavy Atom Count: 14
• Complexity: 208

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NN=CC(=O)OC
• Isomeric SMILES: CC1=CC=C(C=C1)N/N=C/C(=O)OC

Technology Process of methyl (2E)-2-[(4-methylphenyl)hydrazinylidene]acetate

There total 11 articles about methyl (2E)-2-[(4-methylphenyl)hydrazinylidene]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl glyoxylate methyl hemi-acetal (109745-70-2,19757-97-2) + p-tolylhydrazine hydrochloride (637-60-5,35467-65-3) → (E)-2-[2-(4-methylphenyl)hydrazinylidene]acetic acid methyl ester (90918-13-1)

Guidance literature:

With sodium acetate; In methanol; at 20 ℃;

DOI:10.1021/acs.orglett.0c03465

Reference yield: 63.0%

3-azapentane-1,5-diamine (111-40-0,98824-35-2) + 4,4,5,5-tetrafluoro-3-oxo-2-(p-tolyl-hydrazono)-pentanoic acid methyl ester → 2,2,3,3-Tetrafluoro-N-{2-[2-(2,2,3,3-tetrafluoro-propionylamino)-ethylamino]-ethyl}-propionamide + methyl 2-(p-methylphenyl)hydrazonoethanoate (90918-13-1)

Guidance literature:

In methanol; for 48h;

DOI:10.1016/j.jfluchem.2003.11.013

Reference yield: 54.0%

4,4,5,5,6,6,7,7,7-nonafluoro-3-oxo-2-(p-tolyl-hydrazono)-heptanoic acid methyl ester → methyl 2-(p-methylphenyl)hydrazonoethanoate (90918-13-1)

Guidance literature:

With ethylenediamine; In diethyl ether; at 20 ℃; for 24h;

DOI:10.1023/B:RUJO.0000010558.54765.1a

upstream raw materials:

Methyl-hydrogenmesoxalat-p-tolylhydrazon

ethylenediamine

3-azapentane-1,5-diamine

triethylentetramine