1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl-

Base Information

Chemical Name:1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl-
CAS No.:171979-69-4
Molecular Formula:C12H16O
Molecular Weight:176.258
Hs Code.:
Mol file:171979-69-4.mol

Synonyms:5,5-dimethyl-5,6,7,8-tetrahydro-1-naphthol;1,1-Dimethyl-5-tetralol;1,1-Dimethyl-tetralol-(5);1,1-dimethyl-5-tetraol;

Suppliers and Price of 1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl-

Chemical Property:

PSA：20.23000
LogP:3.00610

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl-

There total 1 articles about 1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7712-60-9
5-chloro-2-methyl-pent-2-ene

: 108-95-2,27073-41-2
phenol

: 60326-61-6
5,5-Dimethyl-homochroman

: 171979-69-4
5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-1-ol

Guidance literature:: With potassium carbonate; In acetone;
DOI:10.1021/ja00903a047

Reference yield:

: 171979-69-4
5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-1-ol

: 568-72-9
tanshinone-IIA

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h

2: 71 percent / LiCl, 4A sieves, Me₄Sn, 2,6-di-tert-butylhydroxytoluene / PdCl₂(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr

3: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN₃, Et₃N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H₂O, 25 deg C, 6 h

4: 64 percent / benzene / 24 h / Ambient temperature; Irradiation

5: 84 percent / n-Bu₄NF, O₂ / tetrahydrofuran / 40 h / 25 °C

6: 100 percent / conc. H₂SO₄ / ethanol / 0.75 h / 25 °C

7: 91 percent / DDQ / benzene / 42 h / 25 °C

With dmap; 2,2,2-trifluoroethyl trifluoroacetate; 4 A molecular sieve; sulfuric acid; 2,4-di-t-butyl-3-methyl phenol; tetrabutyl ammonium fluoride; oxygen; tetramethylstannane; triethylamine; Methanesulfonyl azide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium chloride; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; pyridine; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00131a006

Reference yield:

: 171979-69-4
5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-1-ol

: 109664-02-0
5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / DMAP / pyridine / 1.) 0 deg C -> 25 deg C, 1 h, 2.) 25 deg C, 48 h

2: 71 percent / LiCl, 4A sieves, Me₄Sn, 2,6-di-tert-butylhydroxytoluene / PdCl₂(dppf) / dimethylformamide / 12 h / 90 °C / 2585.7 Torr

3: 1.) LiHMDS, 2,2,2-trifluoroethyl trifluoroacetate, 2.) MsN₃, Et₃N / 1.) THF, -78 deg C, 45 min, 2.) MeCN, H₂O, 25 deg C, 6 h

4: 64 percent / benzene / 24 h / Ambient temperature; Irradiation

5: 84 percent / n-Bu₄NF, O₂ / tetrahydrofuran / 40 h / 25 °C

With dmap; 2,2,2-trifluoroethyl trifluoroacetate; 4 A molecular sieve; 2,4-di-t-butyl-3-methyl phenol; tetrabutyl ammonium fluoride; oxygen; tetramethylstannane; triethylamine; Methanesulfonyl azide; lithium chloride; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00131a006