(S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE

Base Information

Chemical Name:(S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE
CAS No.:172097-41-5
Molecular Formula:C25H21N3O3
Molecular Weight:411.46
Hs Code.:
Mol file:172097-41-5.mol

Synonyms:Fmoc-(S)-Phe-CHN2;(S)-1-diazo-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-phenylbutan-2-one;((1S)-benzyl-3-diazo-2-oxo-propyl)carbamic acid 9H-fluoren-9-ylmethyl ester;Fmoc-L-phenylalanyl(diazo)methane;Fmoc-Phe-DAM;FMOC-L-PHE-CHN2;

Suppliers and Price of (S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE 95.00%
1G
$ 1155.00

American Custom Chemicals Corporation
(S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE 95.00%
5MG
$ 504.70

Total 2 raw suppliers

Chemical Property of (S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE

Chemical Property:

PSA：92.79000
LogP:4.47806

Purity/Quality:

97% ^*data from raw suppliers

(S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE

There total 7 articles about (S)-3-FMOC-AMINO-1-DIAZO-3-PHENYL-2-BUTANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 35661-40-6
N-Fmoc L-Phe

: 172097-41-5
(S)-1-diazo-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-phenylbutan-2-one

Guidance literature:: N-Fmoc L-Phe; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 ℃; for 0.0833333h;

diazomethane; In tetrahydrofuran; diethyl ether; at -15 - 20 ℃; for 0.5h; Further stages.;
DOI:10.1021/ja029205t

Reference yield: 92.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 103321-57-9
2S-flouren-9-ylmethoxycarbonylamino-3-phenylpropionyl chloride

: 172097-41-5
(S)-1-diazo-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-phenylbutan-2-one

Guidance literature:: In dichloromethane; for 1h; Ambient temperature;

Reference yield:

: 35661-40-6
N-Fmoc L-Phe

: 172097-41-5
(S)-1-diazo-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-phenylbutan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NMM / tetrahydrofuran / 1 h / -25 °C

2: diethyl ether / 2 h / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(98)00675-3