Technology Process of 1-(2-Methoxyphenyl)cycloheptene
There total 4 articles about 1-(2-Methoxyphenyl)cycloheptene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methoxyphenylmagnesium bromide;
With
tris-(dibenzylideneacetone)dipalladium(0); 4,4,5,5-tetramethyl<1,3,2>dioxaphospholane-2-oxide;
In
tetrahydrofuran;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
cyclohept-1-en-1-yl 4-methylbenzenesulfonate;
In
tetrahydrofuran;
at 60 ℃;
for 22h;
chemoselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201002386
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 5 h / 25 °C / Inert atmosphere
2: bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)palladium(II); 1,3-bis-(diphenylphosphino)propane; lithium carbonate; 1,2-dimethoxybenzene / 72 h / 120 °C / Inert atmosphere
With
pyridine; 1,2-dimethoxybenzene; bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)palladium(II); 1,3-bis-(diphenylphosphino)propane; lithium carbonate;
In
dichloromethane;
2: |Heck Reaction;
DOI:10.1002/chem.201204427
- Guidance literature:
-
With
1,2-dimethoxybenzene; bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)palladium(II); 1,3-bis-(diphenylphosphino)propane; lithium carbonate;
at 120 ℃;
for 72h;
Overall yield = 87 %; Overall yield = 88 mg;
Inert atmosphere;
DOI:10.1002/chem.201204427
