2-cycloheptylphenol

Base Information

• Chemical Name: 2-cycloheptylphenol
• CAS No.: 75120-07-9
• Molecular Formula: C₁₃H₁₈O
• Molecular Weight: 190.285
• Mol file: 75120-07-9.mol

Synonyms:2-cycloheptylphenol

Chemical Property of 2-cycloheptylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cycloheptylphenol

There total 6 articles about 2-cycloheptylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

C13H18O2 → 2-cycloheptylphenol (75120-07-9)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm401037h

Reference yield:

(E)-1-(2-methoxyphenyl)cyclohept-1-en (92862-65-2) → 2-cycloheptylphenol (75120-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C

2: aq. HBr, AcOH

With hydrogen bromide; hydrogen; acetic acid; palladium on activated charcoal;

DOI:10.1039/jr9630000373

Reference yield:

2-hydroxybromobenzene (95-56-7) → 2-cycloheptylphenol (75120-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; diethyl ether / 2 h / 20 °C / Cooling with acetone-dry ice

1.2: 14 h / 20 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With triethylsilane; n-butyllithium; trifluoroacetic acid; In diethyl ether; hexane; dichloromethane;

DOI:10.1021/jm401037h

upstream raw materials:

Cycloheptene

phenol

1-cycloheptyl-2-methoxybenzene

cycloheptyl 4-methylbenzenesulfonate

Refernces

• 1、 Drabkin, A. E.,Fedotov, A. S.,Fedotova, N. F.. "ALKYLATION OF PHENOL WITH CYCLOOLEFINS IN THE PRESENCE OF GLYCERYL SULFATE". . p. 698 - 700. Retrieved 2007/10/02.