Technology Process of 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-,
5-carboxypentyl ester, (1R,2R,3S,5S)-
There total 7 articles about 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-,
5-carboxypentyl ester, (1R,2R,3S,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol; ethyl acetate;
at 20 ℃;
for 0.5h;
DOI:10.1021/ja043935e
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / aq. hydrochloride / 22 h / Heating
2: 48 percent / Me4NOH*5H2O; Et4NI / dimethylformamide; tetrahydrofuran / 20 h / 60 °C
3: 82 percent / Et3N / toluene / 3 h / Heating
4: 90 percent / H2 / Pd/C / ethyl acetate; ethanol / 0.5 h / 20 °C
With
hydrogenchloride; tetramethyl ammoniumhydroxide; tetraethylammonium iodide; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja043935e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 48 percent / Me4NOH*5H2O; Et4NI / dimethylformamide; tetrahydrofuran / 20 h / 60 °C
2: 82 percent / Et3N / toluene / 3 h / Heating
3: 90 percent / H2 / Pd/C / ethyl acetate; ethanol / 0.5 h / 20 °C
With
tetramethyl ammoniumhydroxide; tetraethylammonium iodide; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja043935e
![(1R,2R,3S,5S)-3-Benzoyloxy-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 5-benzyloxycarbonyl-pentyl ester](/Databaselist/images/loading.webp)
