173443-26-0Relevant academic research and scientific papers
MOLECULES THAT STIMULATE THE IMMUNE SYSTEM FOR TREATMENT OF DRUG ADDICTION, METHODS OF SYNTHESIS, ANTIDRUG VACCINE AND USES
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Paragraph 0036; 0176-0179, (2020/12/20)
This technology relates to immune system stimulating molecules to be used in the treatment of drug addiction and abuse and their synthesis processes. These molecules have a calixarene chemical structure, preferably calix[4]arene and/or calix[8]arene, coupled to an hapten analogous to cocaine, preferably GNE and/or GNC. An anti-drug vaccine, specifically anti-cocaine, is also described using such molecules. The anti-drug vaccine can be also used to prevent fetal exposure to drugs in pregnant women who use drugs and do not wish or cannot stop their use during pregnancy.
Fluorescent cocaine probes: A tool for the selection and engineering of therapeutic antibodies
Meijler, Michael M.,Kaufmann, Gunnar F.,Qi, Longwu,Mee, Jenny M.,Coyle, Avery R.,Moss, Jason A.,Wirsching, Peter,Matsushita, Masayuki,Janda, Kim D.
, p. 2477 - 2484 (2007/10/03)
Cocaine is a highly addictive drug, and despite intensive efforts, effective therapies for cocaine craving and addiction remain elusive. In recent years, we and others have reported advances in anti-cocaine immunopharmacotherapy based on specific antibodi
