(20Ξ)-3'',3''-difluoro-2'-(4-fluoro-phenyl)-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-7,3''-dihydro-6H,2'H-cyclopropa[6,7]pregn-4-eno[3,2-c]pyrazol-11β-ol

Base Information

• Chemical Name: (20Ξ)-3'',3''-difluoro-2'-(4-fluoro-phenyl)-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-7,3''-dihydro-6H,2'H-cyclopropa[6,7]pregn-4-eno[3,2-c]pyrazol-11β-ol
• CAS No.: 19449-16-2
• Molecular Formula: C₃₂H₃₅F₃N₂O₅
• Molecular Weight: 584.636

Synonyms:

Chemical Property of (20Ξ)-3'',3''-difluoro-2'-(4-fluoro-phenyl)-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-7,3''-dihydro-6H,2'H-cyclopropa[6,7]pregn-4-eno[3,2-c]pyrazol-11β-ol

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Technology Process of (20Ξ)-3'',3''-difluoro-2'-(4-fluoro-phenyl)-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-7,3''-dihydro-6H,2'H-cyclopropa[6,7]pregn-4-eno[3,2-c]pyrazol-11β-ol

There total 3 articles about (20Ξ)-3'',3''-difluoro-2'-(4-fluoro-phenyl)-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-7,3''-dihydro-6H,2'H-cyclopropa[6,7]pregn-4-eno[3,2-c]pyrazol-11β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorophenyhydrazine hydrochloride (823-85-8) + (20Ξ)-3',3'-difluoro-11β-hydroxy-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-dihydro-cyclopropa[6,7]pregn-4-en-3-one (19449-13-9) + formic acid ethyl ester (109-94-4) → (20Ξ)-3'',3''-difluoro-2'-(4-fluoro-phenyl)-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-7,3''-dihydro-6H,2'H-cyclopropa[6,7]pregn-4-eno[3,2-c]pyrazol-11β-ol (19449-16-2)

Guidance literature:

Multistep reaction; (i) NaH, benzene, (ii) /BRN= 3627721/, aq. NaOAc, MeOH;

DOI:10.1021/jm00310a037

Reference yield:

→ C32H35F3N2O5 (19449-16-2)

Guidance literature:

entspr. Pregn-4-on-11β-ol-3-on, 1. HCOOC2H5, NaH, 2. p-Fluorphenylhydrazin;

Reference yield:

→ 6α,7α-Difluormethylene-11β-hydroxy-16α-methyl-17α,20:20,21-bis(methylendioxy)-2'-(4-fluorphenyl)pregn-4-eno<3,2-c>pyrazol (19449-16-2)

Guidance literature:

11-Keton,NaBH4;

upstream raw materials:

4-fluorophenyhydrazine hydrochloride

(20Ξ)-3',3'-difluoro-11β-hydroxy-17,20;20,21-bis-methanediyldioxy-16α-methyl-(6β,7β)-dihydro-cyclopropa[6,7]pregn-4-en-3-one

formic acid ethyl ester

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