4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-

Base Information

Chemical Name:4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-
CAS No.:1736-24-9
Molecular Formula:C11H8FNO3
Molecular Weight:221.188
Hs Code.:

Synonyms:5-(4-fluorophenyl)-3-methylisoxazole-4-carboxylic acid;3-Methyl-4-carboxy-5-(4-fluor-phenyl)-isoxazol;5-(4-Fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid;

Suppliers and Price of 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-

Chemical Property:

Melting Point:191.5 - 192 °C (aq. ethanol)
Boiling Point:358.7±37.0 °C(Predicted)
PSA：63.33000
Density:1.350±0.06 g/cm3(Predicted)
LogP:2.48730

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl-

There total 3 articles about 4-Isoxazolecarboxylic acid, 5-(4-fluorophenyl)-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 917388-54-6
C₁₂H₁₀FNO₃

: 1736-24-9
5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid

Guidance literature:: C₁₂H₁₀FNO₃; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With oxalic acid; In water; pH=~ 4;

Reference yield:

: 1644-03-7
5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid ethyl ester

: 1736-24-9
5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol;
DOI:10.1039/jr9630005838

Reference yield:

: 146198-68-7
ethyl 2-(4-fluorobenzoyl)acetoacetate

: 1736-24-9
5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NH₂OH*HCl / ethanol

2: aq. KOH / ethanol

With potassium hydroxide; hydroxylamine hydrochloride; In ethanol;
DOI:10.1039/jr9630005838