Benzeneethanol, a-[(phenylmethoxy)methyl]-

Base Information

• Chemical Name: Benzeneethanol, a-[(phenylmethoxy)methyl]-
• CAS No.: 173917-50-5
• Molecular Formula: C16H18O2
• Molecular Weight: 242.318
• Mol file: 173917-50-5.mol

Synonyms:

Chemical Property of Benzeneethanol, a-[(phenylmethoxy)methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanol, a-[(phenylmethoxy)methyl]-

There total 7 articles about Benzeneethanol, a-[(phenylmethoxy)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-hydroxy-3-nitro-3-phenyl-1-benzyloxypropane (906077-32-5) → 3-phenylpropane-1,2-diol (19881-97-1,61475-32-9,79299-22-2,17131-14-5) + 3-(benzyloxy)-1-phenylpropan-2-ol (173917-50-5)

Guidance literature:

With hydrogen; palladium dihydroxide; In ethanol; at 65 ℃; under 750.075 Torr;

DOI:10.1002/anie.200604263

Reference yield: 88.0%

Benzyloxymethyl-oxiran (2930-05-4) + aniline (62-53-3) → 3-(benzyloxy)-1-phenylpropan-2-ol (173917-50-5)

Guidance literature:

With cerium(III) chloride heptahydrate; glycerol; at 20 ℃; for 1h; regioselective reaction;

DOI:10.1055/s-0030-1258366

Reference yield: 64.0%

Benzyloxymethyl-oxiran (2930-05-4) + bromobenzene (108-86-1,52753-63-6) → 3-(benzyloxy)-1-phenylpropan-2-ol (173917-50-5)

Guidance literature:

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 4,4'-bipyridine; NiI₂*3.9H₂O; triethylamine hydrochloride; sodium iodide; zinc; at 20 ℃; for 12h;

DOI:10.1021/ja410704d

upstream raw materials:

Benzyloxymethyl-oxiran

bromobenzene

2-hydroxy-3-nitro-3-phenyl-1-benzyloxypropane

benzyloxyacetoaldehyde

Downstream raw materials:

2-acetoxy-1-benzyloxy-4-phenylpropane

(3-(benzyloxy)-2-bromopropyl)benzene

2-acetoxy-3-phenylpropan-1-ol

(2S)-3-phenyl-propane-1,2-diol diacetate