Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,6-difluorophenyl)methyl]-5-[[methyl(phenylmethyl)amino]methyl]-6-( 4-nitrophenyl)-3-phenyl-

Base Information

• Chemical Name: Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,6-difluorophenyl)methyl]-5-[[methyl(phenylmethyl)amino]methyl]-6-( 4-nitrophenyl)-3-phenyl-
• CAS No.: 174071-70-6
• Molecular Formula: C34H26F2N4O4S
• Molecular Weight: 624.668
• Mol file: 174071-70-6.mol

Synonyms:

Chemical Property of Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,6-difluorophenyl)methyl]-5-[[methyl(phenylmethyl)amino]methyl]-6-( 4-nitrophenyl)-3-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,6-difluorophenyl)methyl]-5-[[methyl(phenylmethyl)amino]methyl]-6-( 4-nitrophenyl)-3-phenyl-

There total 6 articles about Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,6-difluorophenyl)methyl]-5-[[methyl(phenylmethyl)amino]methyl]-6-( 4-nitrophenyl)-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl-methyl-amine (103-67-3) + 5-bromomethyl-1-(2,6-difluorobenzyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (174073-49-5) → 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (174071-70-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N-methyl-acetamide;

Reference yield: 100.0%

benzyl-methyl-amine (103-67-3) + 5-bromomethyl-1-(2,6-difluorobenzyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (174073-49-5) → IR(KBr][hydrochloride] + 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (174071-70-6)

Guidance literature:

With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In N-methyl-acetamide;

Reference yield:

2,6-difluorobenzyl chloride (697-73-4) → 5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (174071-70-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / KI; K₂CO₃ / dimethylformamide / 4 h / 20 °C

2: NBS; AIBN / chlorobenzene / 1.5 h / 90 °C

3: 33.0 g / i-Pr₂NEt / dimethylformamide / 2 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1021/jm020180i

upstream raw materials:

benzyl-methyl-amine

5-bromomethyl-1-(2,6-difluorobenzyl)-6-(4-nitrophenyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

phenyl isocyanate

2,6-difluorobenzyl chloride

Downstream raw materials:

6-(4-aminophenyl)-5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-[3-(2,4-dimethoxybenzyloxy)ureido]phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

C₃₇H₃₃F₂N₅O₄S

C₃₈H₃₅F₂N₅O₄S