1H-Indazole-1-carboxylic acid, 3-[[2,3,4,5-tetrahydro-1-[2-[(1-methylethyl)phenylamino]-2-oxoethyl]-2,4- dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indazole-1-carboxylic acid, 3-[[2,3,4,5-tetrahydro-1-[2-[(1-methylethyl)phenylamino]-2-oxoethyl]-2,4- dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]methyl]-, 1,1-dimethylethyl ester
CAS No.:174181-13-6
Molecular Formula:C39H39N5O5
Molecular Weight:657.769
Hs Code.:

1H-Indazole-1-carboxylic acid,
3-[[2,3,4,5-tetrahydro-1-[2-[(1-methylethyl)phenylamino]-2-oxoethyl]-2,4-
dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]methyl]-, 1,1-dimethylethyl
ester

Synonyms:

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Chemical Property of 1H-Indazole-1-carboxylic acid, 3-[[2,3,4,5-tetrahydro-1-[2-[(1-methylethyl)phenylamino]-2-oxoethyl]-2,4- dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]methyl]-, 1,1-dimethylethyl ester

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Technology Process of 1H-Indazole-1-carboxylic acid, 3-[[2,3,4,5-tetrahydro-1-[2-[(1-methylethyl)phenylamino]-2-oxoethyl]-2,4- dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]methyl]-, 1,1-dimethylethyl ester

There total 7 articles about 1H-Indazole-1-carboxylic acid, 3-[[2,3,4,5-tetrahydro-1-[2-[(1-methylethyl)phenylamino]-2-oxoethyl]-2,4- dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 174180-45-1
2-(2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-(4-methoxy-phenyl)-acetamide

: 174180-42-8
2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate

: 174181-13-6
2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide

Guidance literature:: With potassium hexamethylsilazane; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174181-13-6
2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 53.4 g / DMAP, Et₃N / acetonitrile / 3 h / Ambient temperature

2: 60 percent / NBS, benzoyl peroxide / CCl₄ / 4.5 h / Heating

3: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With dmap; N-Bromosuccinimide; Perbenzoic acid; sodium hexamethyldisilazane; sodium hydride; triethylamine; In tetrachloromethane; acetonitrile;
DOI:10.1021/jm970265x

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 174181-13-6
2-[3-(1-tert-butoxycarbonyl-1H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-N-isopropyl-N-phenyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 53.4 g / DMAP, Et₃N / acetonitrile / 3 h / Ambient temperature

2: 60 percent / NBS, benzoyl peroxide / CCl₄ / 4.5 h / Heating

3: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With dmap; N-Bromosuccinimide; Perbenzoic acid; sodium hexamethyldisilazane; sodium hydride; triethylamine; In tetrachloromethane; acetonitrile;
DOI:10.1021/jm970265x