(2,5-DIMETHOXYPHENYL)ACETYL CHLORIDE

Base Information

• Chemical Name: (2,5-DIMETHOXYPHENYL)ACETYL CHLORIDE
• CAS No.: 52711-92-9
• Molecular Formula: C10H11 Cl O3
• Molecular Weight: 214.649
• Hs Code.: 2918990090
• Mol file: 52711-92-9.mol

Synonyms:Acetylchloride, (2,5-dimethoxyphenyl)- (6CI); (2,5-Dimethoxyphenyl)acetyl chloride;2-(2,5-Dimethoxyphenyl)acetyl chloride

Chemical Property of (2,5-DIMETHOXYPHENYL)ACETYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.000527mmHg at 25°C
• Refractive Index: n20/D 1.5385(lit.)
• Boiling Point: 312.5°Cat760mmHg
• Flash Point: 128°C
• PSA: 35.53000
• Density: 1.2g/cm³
• LogP: 2.01170

Purity/Quality:

99% ^*data from raw suppliers

(2,5-Dimethoxyphenyl)acetyl chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: (2,5-Dimethoxyphenyl)acetyl Chloride is a stain/ dye. Dyes and metabolites.

Technology Process of (2,5-DIMETHOXYPHENYL)ACETYL CHLORIDE

There total 4 articles about (2,5-DIMETHOXYPHENYL)ACETYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

homogentisic acid methyl ester dimethyl ether (6202-39-7) → 2,5-dimethoxyphenylacetyl chloride (52711-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N aq. KOH / benzene / 4 h / Heating

2: thionyl chloride / benzene / 3 h / Heating

With potassium hydroxide; thionyl chloride; In benzene;

Reference yield:

(2,5-dimethoxyphenyl)acetic acid (1758-25-4) → 2,5-dimethoxyphenylacetyl chloride (52711-92-9)

Guidance literature:

With thionyl chloride; In benzene; for 3h; Heating;

Reference yield:

→ Sulfamic acid [2,5-dimethoxyphenyl(acetyl)]-2,6-bis(1-methylethyl)-phenyl ester + 2,5-dimethoxyphenylacetyl chloride (52711-92-9)

Guidance literature:

upstream raw materials:

(2,5-dimethoxyphenyl)acetic acid

homogentisic acid methyl ester dimethyl ether

Downstream raw materials:

ent-18α-[(2,5-dimethoxy-phenyl)-acetoxy]-11,17β-dimethoxy-15β-yohimban-16α-carboxylic acid methyl ester

N,N-di-n-propyl-2-(2,5-dimethoxyphenyl)acetamide

4-(2,5-dimethoxy-phenyl)-2-methyl-buta-2,3-dienoic acid isobutyl ester

4-(2,5-dimethoxy-phenyl)-3-oxo-butyric acid ethyl ester

Refernces

• 1、 Salado, Irene G.,Redondo, Miriam,Bello, Murilo L.,Perez, Concepción,Liachko, Nicole F.,Kraemer, Brian C.,Miguel, Laetitia,Lecourtois, Magalie,Gil, Carmen,Martinez, Ana,Perez, Daniel I.. "Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis". . p. 2755 - 2772. Retrieved 2014/04/17.
• 2、 Fish, Paul V.,Brown, Alan D.,Evrard, Edel,Roberts, Lee R.. "7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: Hit-to-lead optimization". scheme or table. p. 1871 - 1875. Retrieved 2009/12/03.