1758-25-4

Usage

Uses

Used in Pharmaceutical Industry:
(2,5-Dimethoxyphenyl)acetic acid is used as a pharmaceutical intermediate for [application reason] the synthesis of various drugs and medications. Its unique chemical structure allows it to be a key component in the development of new pharmaceuticals, contributing to the advancement of medical treatments.
Used in Organic Synthesis:
In the field of organic chemistry, (2,5-Dimethoxyphenyl)acetic acid serves as a useful reagent for [application reason] facilitating various chemical reactions and the creation of new organic compounds. Its versatility in organic synthesis makes it an essential tool for researchers and chemists working on the development of novel molecules and materials.
Note: The "application reason" part in the usage section would be filled based on the specific reason why (2,5-Dimethoxyphenyl)acetic acid is used in each application. Since the provided materials do not give specific reasons, I have left it as a placeholder for you to fill in with the appropriate information.

InChI:InChI=1/C10H12O4/c1-13-8-3-4-9(14-2)7(5-8)6-10(11)12/h3-5H,6H2,1-2H3,(H,11,12)/p-1

Upstream product

• 18086-24-3 2-(2,5-dimethoxyphenyl)acetonitrile 
• 6202-39-7 homogentisic acid methyl ester dimethyl ether 
• 108-24-7 acetic anhydride 
• 150-78-7 1,4-dimethoxybezene 
• 1201-38-3 2',5'-dimethoxyacetophenone 
• 446831-24-9 1-bromo-4-chloromethyl-2,5-dimethoxy-benzene 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 24599-58-4 2,5-dimethoxy toluene 
• 3840-27-5 2,5-dimethoxybenzyl chloride 
• 151-50-8 potassium cyanide 
• 124-38-9 carbon dioxide 
• 60732-17-4 2,5-dimethoxybenzyl bromide 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 

Downstream Products

• 66469-86-1 ethyl (2,5-dimethoxyphenyl)acetate 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 521308-60-1 N-(4-butylamino-6-chloropyrimidin-5-yl)-2-(2,5-dimethoxyphenyl)acetamide 
• 873209-08-6 2-(2,5-dimethoxy-phenyl)-N-(2,4,6-triamino-pyrimidin-5-yl)-acetamide 
• 43021-98-3 3-(2,5-dimethoxyphenyl)-2-oximinopropane 
• 108014-58-0 (3,5-dinitro-phenyl)-carbamic acid-(2,5-dimethoxy-phenethyl ester) 
• 3914-94-1 (2,5-dimethoxy-4-nitrophenyl)acetic acid 
• 403499-16-1 (3S)-5-[(2-chloro-6-fluorobenzyl)oxy]-3-{[(2S)-2-{[(2,5-dimethoxyphenyl)acetyl]amino}-3-methylbutanoyl]amino}-4-oxo-pentanoic Acid 
• 1490389-27-9 di-tert-butyl octane-1,8-diylbis((3-(2-(2,5-dimethoxyphenyl)acetamido)propyl)carbamate) 
• 1490389-74-6 di-tert-butyl dodecane-1,12-diylbis(3-(2-(2,5-dimethoxyphenyl)acetamido)propylcarbamate) 
• 1450604-62-2 (αE)-α-[[1-acetyl-5-(phenylmethoxy)-1H-indol-3-yl]methylene]-2,5-dimethoxybenzeneacetic acid 
• 1393101-88-6 6-(2,5-dimethoxybenzyl)-3,7-dimethylquinoline-5,8-dione 
• 1393101-80-8 7-(2,5-dimethoxybenzyl)-3,6-dimethylquinoline-5,8-dione 
• 1393101-65-9 7-(2,5-dimethoxybenzyl)-6-methylquinoline-5,8-dione 

Relevant academic research and scientific papers

Preparation method of 2,5-dimethoxyphenylacetic acid

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of 2,5-dimethoxyphenylacetic acid, wherein the method comprises the following steps: A,reacting 1,4-dimethoxybenzene in a formylation system to obtain 2,5-dimethoxybenzaldehyde; B, reacting the 2,5-dimethoxybenzaldehyde obtained in the step A with a reducing agent, extracting a reaction system, then combining organic phases, drying, concentrating under reduced pressure and distilling a crude product to obtain 2,5-dimethoxybenzyl alcohol; C, reacting the 2,5-dimethoxybenzyl alcoholobtained in the step B with a bromination reagent to obtain 2-bromomethyl-1,4-dimethoxybenzene; and D, reacting the 2-bromomethyl-1,4-dimethoxybenzene obtained in the step C with magnesium or butyl lithium and carbon dioxide in a solvent to obtain the 2,5-dimethoxyphenylacetic acid. The yield and the total yield of the 2,5-dimethoxyphenylacetic acid obtained by the method disclosed by the invention are both higher than those of 2,5-dimethoxyphenylacetic acid synthesized by a Willegerdt-Kindler method.

Preparation method of 2, 5-dimethoxyphenylacetic acid

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of 2, 5-dimethoxyphenylacetic acid, which comprises the following steps: A. Reacting 1,4-dimethoxybenzene with formaldehyde under the action of hydrogen halide, extracting by the reaction system, merging with organic phases, drying, concentrating under reduced pressure, and purifying the crude product to obtain 2-halon methyl-1, 4-dimethoxybenzene ; and B, under the protection of inert gas, putting the 2-halo methyl-1, 4-dimethoxybenzene obtained in the step A, magnesium or butyl lithium and carbon dioxide into a solvent, and then carrying out extraction and deactivation, reduced pressure distillation, extraction, organic phase combination and reduced pressure concentration toobtain the 2, 5-dimethoxyphenylacetic acid. The yield and the total yield of the 2, 5-dimethoxyphenylacetic acid obtained by the method disclosed by the invention are both higher than those of the 2,5-dimethoxyphenylacetic acid synthesized by a Willgerodt-Kindler method.

Preparation method of 2,5-dimethoxyphenylacetic acid

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of 2,5-dimethoxyphenylacetic acid, wherein the preparation method comprises the following steps: A, reacting 1,4-dimethoxybenzene with formaldehyde under the action of hydrogen halide to obtain 2-halomethyl-1,4-dimethoxybenzene; B, reacting 2-halomethyl-1,4-dimethoxybenzene obtained inthe step A with a cyanation reagent, then diluting, washing, drying and concentrating under reduced pressure, and finally carrying out reduced pressure distillation to obtain 2(2,5-dimethoxyphenyl)acetonitrile; and C, hydrolyzing the 2(2,5-dimethoxyphenyl)acetonitrile obtained in the step B, cooling, extracting, merging, drying, concentrating under reduced pressure and purifying to finally obtainthe 2,5-dimethoxyphenylacetic acid. The yield and the total yield of the 2,5-dimethoxyphenylacetic acid obtained by the method disclosed by the invention are both higher than those of the 2,5-dimethoxyphenylacetic acid synthesized by a Willgerodt-Kindler method, and the yield and the total yield of the 2,5-dimethoxyphenylacetic acid are higher than those of 2,5-dimethoxyphenylacetic acid synthesized by the Willgerodt-Kindler method.

Organic Synthesis with α-Chloro Sulphides. Preparation of Aromatic γ-Lactones from Phenols and α-Chloro Sulphide Carboxylates

Lewis acid-catalysed alkylation of para-substituted phenols using α-chloro sulphides as electrophiles yields sulphenylated γ-lactones which can be desulphurised with zinc in acetic acid or Raney nickel.This synthesis has been applied to p-cresol, 2-naphthol, and two phenolic dihydrocinnamates.Alkylation of 1,4-dimethoxybenzene yields homogentisic acid dimethyl ether after desulphurisation and hydrolysis.

Syntheses of Covalently-Linked Porphyrin-Quinone Complexes (1)

A synthetic route for the preparation of covalently-linked porphyrin-quinone and metalloporphyrin-quinone complexes as models for the phototrap in bacterial photosynthesis is described. 5-(4-Carboxyphenyl)-10,15,20-tritolylporphyrin, prepared by a mixed aldehyde approach, was attached to a benzoquinone center with a propanediol bridge by means of ester linkages.The starting point for the benzoquinone moiety was 2,5-dihydroxyphenylacetic acid, whose hydroquinone function was first protected by preparing its dimethylether.The spacing between the two centers of the complex could be altered simply by varying the length of the bridging group (a diol) employed.Boron tribromide was used to unmask the quinol derivatives in the final coupled products.The zinc(II) derivative of porphyrin quinone comple was prepared ba addition of a saturated solution of zinc acetate in methanol to a solution of the corresponding porphyrin-hydroquinone complex in dichloromethane at room temperature.The structures of these complexes were confirmed by nmr spectroscopy, uv-visible absorption, and mass spectroscopy.Oxidation of the quinol moiety in the covalently-linked complex to its corresponding quinonoid derivative was accomplished by treating a solution of the complex in dichloromethane with a stoichiometric amount of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, a high potential benzoquinone.