2-Propenamide, N,N-dimethyl-3-phenyl-, (2E)-

Base Information

• Chemical Name: 2-Propenamide, N,N-dimethyl-3-phenyl-, (2E)-
• CAS No.: 17431-39-9
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Mol file: 17431-39-9.mol

Synonyms:

Chemical Property of 2-Propenamide, N,N-dimethyl-3-phenyl-, (2E)-

Chemical Property:

• Melting Point: 120 °C
• Boiling Point: 335.1±21.0 °C(Predicted)
• PKA: -0.69±0.70(Predicted)
• PSA: 0.00000
• Density: 1.044±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

(2E)-N,N-Dimethyl-3-phenylprop-2-enamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenamide, N,N-dimethyl-3-phenyl-, (2E)-

There total 89 articles about 2-Propenamide, N,N-dimethyl-3-phenyl-, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(E)-3-phenylacrylic acid (140-10-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (E)-N,N-dimethylcinnamamide (17431-39-9)

Guidance literature:

With sulfur trioxide pyridine complex; at 160 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1246/cl.171216

Reference yield: 97.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + benzaldehyde (100-52-7) → (E)-N,N-dimethylcinnamamide (17431-39-9)

Guidance literature:

N,N-dimethyl acetamide; With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; sulfuric acid; at 20 ℃; for 1h; Inert atmosphere;

benzaldehyde; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.07.129

Reference yield: 96.0%

iodobenzene (591-50-4) + N,N-Dimethylacrylamide (2680-03-7,68761-83-1) → (E)-N,N-dimethylcinnamamide (17431-39-9)

Guidance literature:

With dicyclohexylmethylamine; 1-(4-hydroxyphenyl)ethanone oxime; In water; for 14h; Heating;

DOI:10.1021/jo0502551

upstream raw materials:

N,N-dimethyl(trimethylsilyl)acetamide

benzaldehyde

styrene

iodobenzene

Downstream raw materials:

1,3-diphenyl-propen-3-one

4-Cyano-N,N-dimethyl-4-naphthalen-1-yl-3-phenyl-butyramide

(2S,3S)-2,3-Diphenyl-pentanedioic acid 1-dicyclohexylamide 5-dimethylamide

(2S,3R)-2,3-Diphenyl-pentanedioic acid 1-dicyclohexylamide 5-dimethylamide

Refernces

• 1、 Spaargaren et al.. "". . p. 965,968, 974. Retrieved 1972.
• 2、 Wu, Xiaofang,Zhou, Lei,Li, Fangshao,Xiao, Jing. "PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation". . p. 491 - 497. Retrieved 2021/01/20.
• 3、 Matsumoto, Shoji,Marumoto, Hayato,Akazome, Motohiro,Otani, Yasuhiko,Kaiho, Tatsuo. "Chemoselective reduction of ?,￠-unsaturated carbonyl and carboxylic compounds by hydrogen iodide". . p. 590 - 599. Retrieved 2021/03/29.