1H-Isoindol-1-one, 2,3-dihydro-3-methyl-, (3S)-

Base Information

Chemical Name:1H-Isoindol-1-one, 2,3-dihydro-3-methyl-, (3S)-
CAS No.:174392-23-5
Molecular Formula:C9H9NO
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID60449517
Nikkaji Number:J2.561.163B

Synonyms:174392-23-5;1H-Isoindol-1-one, 2,3-dihydro-3-methyl-, (3S)-;(3S)-3-METHYL-2,3-DIHYDROISOINDOL-1-ONE;(3S)-Methyl-2,3-dihydro-isoindol-1-one;SCHEMBL19573960;DTXSID60449517;(3S)-3beta-Methyl-2,3-dihydro-1H-isoindole-1-one

Suppliers and Price of 1H-Isoindol-1-one, 2,3-dihydro-3-methyl-, (3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-Isoindol-1-one, 2,3-dihydro-3-methyl-, (3S)-

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:147.068413911
Heavy Atom Count:11
Complexity:178

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C2=CC=CC=C2C(=O)N1
Isomeric SMILES:C[C@H]1C2=CC=CC=C2C(=O)N1

Technology Process of 1H-Isoindol-1-one, 2,3-dihydro-3-methyl-, (3S)-

There total 5 articles about 1H-Isoindol-1-one, 2,3-dihydro-3-methyl-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1015198-84-1
(R)-methyl 2-[(N-t-butylsulfinylimine)methyl]benzoate

: 75-16-1
methylmagnesium bromide

: 131615-22-0
(3R)-3-Methyl-2,3-dihydro-1H-isoindol-1-one

: 174392-23-5
(S)-3-methyl-2,3-dihydro-1H-isoindolin-1-one

Guidance literature:: In diethyl ether; dichloromethane; at 20 ℃; for 2h; Overall yield = 90 %; Overall yield = 46 mg; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2017.12.035

Reference yield:

: 29879-70-7
3-hydroxy-3-methylisoindolin-1-one

: 131615-22-0
(3R)-3-Methyl-2,3-dihydro-1H-isoindol-1-one

: 174392-23-5
(S)-3-methyl-2,3-dihydro-1H-isoindolin-1-one

Guidance literature:: With (R)-2,2'-diphenyl-3,3'-biphenanthryl-4,4'-diyl phosphate; di-tert-butyl 1,4-dihydro-2,6-dimethyl-3,5-pyridine-dicarboxylate; In dichloromethane; at 35 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc16832d

Reference yield:

: 1077-79-8
methyl 2-acetylbenzoate

: 131615-22-0
(3R)-3-Methyl-2,3-dihydro-1H-isoindol-1-one

: 174392-23-5
(S)-3-methyl-2,3-dihydro-1H-isoindolin-1-one

Guidance literature:: With Ru⁽²⁺⁾*2C₂H₃O₂^(1-)*C₇₇H₁₀₈O₆P₂; ammonium acetate; hydrogen; In 2,2,2-trifluoroethanol; at 90 ℃; for 24h; Overall yield = 85 percent; enantioselective reaction; Autoclave;
DOI:10.1021/acs.orglett.0c00669