2-benzyl-3-hydroxy-1-isoindolinone

Base Information

• Chemical Name: 2-benzyl-3-hydroxy-1-isoindolinone
• CAS No.: 17448-14-5
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Mol file: 17448-14-5.mol

Synonyms:3-hydroxy-2benzyl-2,3-dihydroisoindol-1-one;2-benzyl-3-hydroxyisoindolin-1-one;2-Benzyl-3-hydroxy-isoindolin-1-on;2-benzyl-3-hydroxy-2,3-dihydro-isoindol-1-one;

Chemical Property of 2-benzyl-3-hydroxy-1-isoindolinone

Chemical Property:

• PSA: 40.54000
• LogP: 2.27140

Purity/Quality:

2-BENZYL-3-HYDROXY-1-ISOINDOLINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-benzyl-3-hydroxy-1-isoindolinone

There total 16 articles about 2-benzyl-3-hydroxy-1-isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-benzylphthalimide (2142-01-0) → 2-benzyl-3-hydroxy-2,3-dihydro-isoindol-1-one (17448-14-5)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; Triethoxysilane; zinc(II) acetate dihydrate; In tetrahydrofuran; at 70 ℃; Reagent/catalyst; Solvent; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201400961

Reference yield: 98.0%

2-benzyl-3-phenylsulfanyl-2,3-dihydro-isoindol-1-one (222713-05-5) → 2-benzyl-3-hydroxy-2,3-dihydro-isoindol-1-one (17448-14-5)

Guidance literature:

With copper(I) bromide; In water; acetonitrile; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2003.09.204

Reference yield: 71.0%

3-Bromophthalide (6940-49-4) + dibenzylamine (103-49-1) → 2-benzyl-3-hydroxy-2,3-dihydro-isoindol-1-one (17448-14-5) + 2-benzyl-3-(benzylamino)-2,3-dihydro-1H-isoindol-1-one

Guidance literature:

In chloroform; for 1h; Ambient temperature;

upstream raw materials:

N-benzylphthalimide

3-Bromophthalide

dibenzylamine

3-chloro-1(3H)-isobenzofuranone

Downstream raw materials:

2-benzyl-3-(2-hydroxyphenyl)isoindolin-1-one

2-Benzyl-3-(4-hydroxy-phenyl)-2,3-dihydro-isoindol-1-one

3-(carboxymethylthio)-2,3-dihydro-2-(phenylmethyl)-1H-isoindol-1-one

3-Amino-2-benzyl-2,3-dihydro-isoindol-1-one