Malonic acid, (p-hydroxybenzylidene)-, cyclic isopropylidene ester

Base Information

• Chemical Name: Malonic acid, (p-hydroxybenzylidene)-, cyclic isopropylidene ester
• CAS No.: 17474-27-0
• Molecular Formula: C13H12O5
• Molecular Weight: 248.235
• Mol file: 17474-27-0.mol

Synonyms:

Chemical Property of Malonic acid, (p-hydroxybenzylidene)-, cyclic isopropylidene ester

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Malonic acid, (p-hydroxybenzylidene)-, cyclic isopropylidene ester

There total 3 articles about Malonic acid, (p-hydroxybenzylidene)-, cyclic isopropylidene ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cycl-isopropylidene malonate (2033-24-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-(4-hydroxy-benzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione (17474-27-0)

Guidance literature:

at 50 ℃; for 1h;

DOI:10.1016/S0040-4020(03)00554-4

Reference yield: 93.0%

cycl-isopropylidene malonate (2033-24-1) + α-(4-hydroxyphenyl)-N-phenyl nitrone (2878-50-4,94664-72-9) → 5-(4-hydroxy-benzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione (17474-27-0)

Guidance literature:

In ethanol; for 0.5h; Reflux; Green chemistry;

Reference yield:

→ 5-(4-hydroxy-benzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione (17474-27-0)

Guidance literature:

Meldrumsaeure, 4-Hydroxy-benzaldehyd , CHCl3;

DOI:10.1007/BF00909251

upstream raw materials:

cycl-isopropylidene malonate

4-hydroxy-benzaldehyde

α-(4-hydroxyphenyl)-N-phenyl nitrone

Downstream raw materials:

2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

Ethyl (3S)-3-[4-[[4-[(tert-butyl(diphenyl)silyl)oxymethyl]-3-methyl-phenyl]methoxy]phenyl]hex-4-ynoate

C₁₇H₁₈O₄

4-(4-hydroxyphenyl)-3,4-dihydro-2H-benzo[g]chromene-2,5,10-trione

Refernces

• 1、 Ye, Zhiwen,Liu, Chunxia,Zou, Feng,Cai, Yan,Chen, Bin,Zou, Yuxing,Mo, Jiaxian,Han, Ting,Huang, Wenlong,Qiu, Qianqian,Qian, Hai. "Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents". . . Retrieved 2020/06/19.
• 2、 -. "3-PHENYL-4-HEXYNOIC ACID DERIVATIVES AS GPR40 AGONISTS". Page/Page column 38. . Retrieved 2019/07/23.