2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

Base Information

Chemical Name:2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione
CAS No.:865233-82-5
Molecular Formula:C₁₈H₂₀O₆
Molecular Weight:332.353
Hs Code.:

Synonyms:2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

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Chemical Property of 2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

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Technology Process of 2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

There total 2 articles about 2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 17474-27-0
5-(4-hydroxy-benzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione

: 865233-82-5
2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 3.5h; Heating / reflux;

Reference yield:

: 2033-24-1
cycl-isopropylidene malonate

: 865233-82-5
2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: water; toluene / 4.67 h / 23 - 33 °C / Large scale reaction

2: pyridinium p-toluenesulfonate / dichloromethane / 40 °C

With pyridinium p-toluenesulfonate; In dichloromethane; water; toluene; 1: Knoevenagel condensation;
DOI:10.1021/op1003055

Reference yield: 52.0%

: 865233-82-5
2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione

: 75-16-1
methylmagnesium bromide

: 1073546-66-3
ethyl 3-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)butanoate

Guidance literature:: 2,2-Dimethyl-5-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-[1,3]dioxane-4,6-dione; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; for 0.833333h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

With pyridine; ethanol; at 90 ℃; for 77h;