4-Chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)pyridine

Base Information

Chemical Name:4-Chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)pyridine
CAS No.:175140-35-9
Molecular Formula:C16H18ClNO
Molecular Weight:275.778
Hs Code.:
DSSTox Substance ID:DTXSID70432632
Wikidata:Q82246710

Synonyms:4-chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)pyridine;175140-35-9;SCHEMBL5845112;DTXSID70432632;VCWZKGKDTSYFIG-UHFFFAOYSA-N;4-chloro-2,5-dimethyl-6-(2,4,6-trimethylphenoxy)-pyridine;4-Chloro-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine;4-Chloro-3,6-dimethyl-2-(2,4,6-trimethyl-phenyoxy)-pyridine;4-chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-pyridine

Suppliers and Price of 4-Chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)pyridine

Chemical Property:

PSA：22.12000
LogP:5.06930
XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:275.1076919
Heavy Atom Count:19
Complexity:287

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C(=C1)C)OC2=NC(=CC(=C2C)Cl)C)C

Technology Process of 4-Chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)pyridine

There total 4 articles about 4-Chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4-chloro-2,5-dimethyl-6-(2,4,6-trimethyl-phenoxy)-pyridine 1-oxide

: 175140-35-9
4-Chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-pyridine

Guidance literature:: With phosphorus trichloride; In dichloromethane; for 0.5h; Heating;
DOI:10.1021/jm070578k

Reference yield: 61.0%

: 83791-90-6
2,4-dichloro-3,6-dimethylpyridine

: 527-60-6
Mesitol

: 175140-35-9
4-Chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-pyridine

Guidance literature:: With pyridine; copper(l) iodide; potassium tert-butylate; for 2h; regioselective reaction; Inert atmosphere; Reflux; Large scale;
DOI:10.1021/op800004q

Reference yield:

: 4664-13-5
2,4-dihydroxy-3,6-dimethylpyridine

: 175140-35-9
4-Chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-diethylaniline; trichlorophosphate / 2 h / 90 - 95 °C / Inert atmosphere; Large scale

2: copper(l) iodide; pyridine; potassium tert-butylate / 2 h / Inert atmosphere; Reflux; Large scale

With pyridine; copper(l) iodide; potassium tert-butylate; N,N-diethylaniline; trichlorophosphate;
DOI:10.1021/op800004q