Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-

Base Information

Chemical Name:Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-
CAS No.:175139-41-0
Molecular Formula:C21H29NO2
Molecular Weight:
Hs Code.:
UNII:GNW87JO5PF
DSSTox Substance ID:DTXSID50431305
Nikkaji Number:J2.731.167I
Pharos Ligand ID:74W1VJB6NTH2
ChEMBL ID:CHEMBL270738

Synonyms:4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridine;CP 316311;CP-316311;CP316311

Suppliers and Price of Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-

Chemical Property:

XLogP3:6.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:327.219829168
Heavy Atom Count:24
Complexity:359

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(CC)OC1=C(C(=NC(=C1)C)OC2=C(C=C(C=C2C)C)C)C
Recent ClinicalTrials:Multicentre Trial to Evaluate the Safety and Efficacy of CP-316,311 in Major Depressive Disorder

Technology Process of Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-

There total 3 articles about Pyridine, 4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 175140-35-9
4-Chloro-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-pyridine

: 584-02-1
2-pentanol

: 175139-41-0
4-(1-Ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine

Guidance literature:: With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 130 ℃; for 3h;
DOI:10.1021/jm070578k

Reference yield:

: 4664-13-5
2,4-dihydroxy-3,6-dimethylpyridine

: 175139-41-0
4-(1-Ethyl-propoxy)-3,6-dimethyl-2-(2,4,6-trimethyl-phenoxy)-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diethylaniline; trichlorophosphate / 2 h / 90 - 95 °C / Inert atmosphere; Large scale

2: copper(l) iodide; pyridine; potassium tert-butylate / 2 h / Inert atmosphere; Reflux; Large scale

3: potassium tert-butylate / tetrahydrofuran / 4 h / 120 °C / Inert atmosphere; Large scale

With pyridine; copper(l) iodide; potassium tert-butylate; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/op800004q