2-(Benzyloxy)-6-bromo[1,3]oxazolo[4,5-b]pyridine

Base Information

Chemical Name:2-(Benzyloxy)-6-bromo[1,3]oxazolo[4,5-b]pyridine
CAS No.:175424-24-5
Molecular Formula:C13H9BrN2O2
Molecular Weight:305.131
Hs Code.:
DSSTox Substance ID:DTXSID30597872
Wikidata:Q82493531

Synonyms:175424-24-5;2-(Benzyloxy)-6-bromo[1,3]oxazolo[4,5-b]pyridine;SCHEMBL8626775;DTXSID30597872;OOAIOSJOQRVRCR-UHFFFAOYSA-N;2-benzyloxy-6-bromooxazolo[4,5-b]pyridine

Suppliers and Price of 2-(Benzyloxy)-6-bromo[1,3]oxazolo[4,5-b]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(Benzyloxy)-6-bromo[1,3]oxazolo[4,5-b]pyridine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:303.98474
Heavy Atom Count:18
Complexity:274

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC2=NC3=C(O2)C=C(C=N3)Br

Technology Process of 2-(Benzyloxy)-6-bromo[1,3]oxazolo[4,5-b]pyridine

There total 1 articles about 2-(Benzyloxy)-6-bromo[1,3]oxazolo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21594-52-5
6-bromo-3H-oxazolo[4,5-b]pyridin-2-one

: 100-39-0
benzyl bromide

: 106691-30-9
3-benzyl-6-bromooxazolo<4,5-b>pyridine-2(3H)-one

: 175424-24-5
2-Benzyloxy-6-bromo-oxazolo[4,5-b]pyridine

Guidance literature:: With ethanol; sodium; Yield given. Multistep reaction. Yields of byproduct given; 1.) room temperature 1 h, 2.) DMF, reflux, 2 h.;
DOI:10.1016/S0040-4020(97)00179-8

Reference yield: 56.0%

: 100-39-0
benzyl bromide

: 175424-24-5
2-Benzyloxy-6-bromo-oxazolo[4,5-b]pyridine

: 189563-96-0
6-Benzyl-2-benzyloxy-oxazolo[4,5-b]pyridine

Guidance literature:: With chloro-trimethyl-silane; ethylene dibromide; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 50 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(97)00179-8

Reference yield:

: 175424-24-5
2-Benzyloxy-6-bromo-oxazolo[4,5-b]pyridine

: 6-benzoyloxazolo[4,5-b]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / Zn, 1,2-dibromoethane, CiSiMe₃ / tetrakis (triphenylphosphine) palladium ⁽⁰⁾ / tetrahydrofuran / 0.33 h / 50 °C

2: 1.) CrO₃, tBuOOH, 2.) H₂ / 2.) 10percent Pd/C / 1.) CH₂Cl₂, H₂O, 24 h, 2 .) MeOH, 40 psi, 18 h.

With chromium(VI) oxide; tert.-butylhydroperoxide; chloro-trimethyl-silane; hydrogen; ethylene dibromide; zinc; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1016/S0040-4020(97)00179-8