(3-Methylpyridin-2-yl)methanaminium

Base Information

• Chemical Name: (3-Methylpyridin-2-yl)methanaminium
• CAS No.: 153936-26-6
• Molecular Formula: 7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20934878
• Wikidata: Q72496633
• Mol file: 153936-26-6.mol

Synonyms:DTXSID20934878;(3-methylpyridin-2-yl)methanaminium

Chemical Property of (3-Methylpyridin-2-yl)methanaminium

Chemical Property:

• Vapor Pressure: 0.126mmHg at 25°C
• Boiling Point: 218.4 °C at 760 mmHg
• Flash Point: 106.5 °C
• PSA: 38.91000
• Density: 1.027 g/cm³
• LogP: 1.54900
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 123.092223359
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3-Methylpyridin-2-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)C[NH3+]
• Uses: 2-AMINOMETHYL-3-METHYLPYRIDINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of (3-Methylpyridin-2-yl)methanaminium

There total 2 articles about (3-Methylpyridin-2-yl)methanaminium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-cyano-3-methylpyridine (20970-75-6) → C-(3-methyl-pyridin-2-yl)-methylamine (153936-26-6)

Guidance literature:

With hydrogen; In ethanol; at 20 ℃; for 4h;

Reference yield: 53.0%

→ C-(3-methyl-pyridin-2-yl)-methylamine (153936-26-6)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; water; at 20 ℃; under 3800.26 Torr; Autoclave;

With potassium carbonate; In water;

Reference yield: 100.0%

3-methylpyridine-2-carboxaldehyde (55589-47-4) + C-(3-methyl-pyridin-2-yl)-methylamine (153936-26-6) → (E)-1-(3-methylpyridin-2-yl)-N-((3-methylpyridin-2-yl)methylene)methanamine

Guidance literature:

3-methylpyridine-2-carboxaldehyde; C-(3-methyl-pyridin-2-yl)-methylamine; In dichloromethane; for 0.0833333h; Inert atmosphere;

With sodium sulfate; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere; Darkness;

DOI:10.1002/anie.201505608

upstream raw materials:

2-cyano-3-methylpyridine

Downstream raw materials:

(R)-3-((2S,4R)-4-Benzyl-5-oxo-tetrahydro-furan-2-carbonyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid (3-methyl-pyridin-2-ylmethyl)-amide

N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-phenylpyrimidine-4-carboxamide

N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(2-fluorophenyl)pyrimidine-4-carboxamide

N-((3-methyl-pyridin-2-yl)methyl)-2-amino-6-(3-fluorophenyl)pyrimidine-4-carboxamide

Refernces

• 1、 -. "PRODUCTION METHOD OF OPTICALLY ACTIVE SECONDARY ALCOHOL". Paragraph 0127; 0129. . Retrieved 2016/11/14.
• 2、 -. "TACHYKININ RECEPTOR ANTAGONISTS". Page 28. . Retrieved 2010/02/10.