55589-47-4

Basic information

• Product Name: 3-METHYL-2-PYRIDINECARBOXALDEHYDE
• Synonyms: 2-FORMYL-3-PICOLINE;3-METHYL-2-PYRIDINALDEHYDE;3-METHYL-2-PYRIDINECARBOXALDEHYDE;3-METHYL-PYRIDINE-2-CARBALDEHYDE;3-Methylpicolinaldehyde;3 - methyl -2 - pyridine formaldehyde;3-Methylpyridine-2-carboxaldehyde;3-Methylpyridine-2-carboxaldehyde,3-Methylpyridine-2-carbaldehyde
• CAS NO: 55589-47-4
• Molecular Formula: C₇H₇NO
• Molecular Weight: 121.14
• Product Categories: Pyridine;pharmacetical;Pyridine series;Aldehydes;Pyridines;Building Blocks;C7;C7 to C8;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks;NULL
• Mol File: 55589-47-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 8°C(lit.)
• Boiling Point: 84°C/13mmHg(lit.)
• Flash Point: 74 °C
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.080 g/mL at 25 °C
• Vapor Pressure: 0.231mmHg at 25°C
• Refractive Index: n20/D 1.538
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.22±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-METHYL-2-PYRIDINECARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-2-PYRIDINECARBOXALDEHYDE(55589-47-4)
• EPA Substance Registry System: 3-METHYL-2-PYRIDINECARBOXALDEHYDE(55589-47-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 55589-47-4(Hazardous Substances Data)

Usage

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

InChI:InChI=1/C7H7NO/c1-6-3-2-4-8-7(6)5-9/h2-5H,1H3

Upstream product

• 52814-41-2 2-(acetoxymethyl)-3-methylpyridine 
• 583-61-9 2,3-Lutidine 
• 67-56-1 methanol 
• 3430-17-9 2-bromo-3-picoline 
• 68-12-2 N,N-dimethyl-formamide 
• 22710-07-2 2,3-dimethylpyridine 1-oxide 
• 63071-09-0 2-hydroxymethyl-3-methyl pyridine 

Downstream Products

• 101870-40-0 3-methyl-pyridine-2-carbaldehyde oxime 
• 106911-02-8 4-methyl-[1,2,3]triazolo[1,5-a]pyridine 
• 1365627-22-0 C₂₅H₂₇N₅O 
• 22382-94-1 3-methyl-2-vinylpyridine 
• 1298133-36-4 (R)-N-(3-methylpyridine-2-methyl)-7-bis-(3,5-di-tert-butylphenyl)phosphino-7′-amino-1,1′-spirodihydroindane 
• 1269771-55-2 1-methyl-2-(3-methylpyridin-2-yl)-1H-benzimidazole 
• 880361-72-8 N-methyl-1-(3-methylpyridin-2-yl)methylamine 

Relevant articles and documents

Synthesis and anti-hiv activity of a novel series of isoquinoline-based cxcr4 antagonists

An expansion of the structure–activity relationship study of CXCR4 antagonists led to the synthesis of a series of isoquinolines, bearing a tetrahydroquinoline or a 3-methylpyridinyl moiety as head group. All compounds were investigated for CXCR4 affinity and antagonism in competition binding and calcium mobilization assays, respectively. In addition, the anti-HIV activity of all analogues was determined. All compounds showed excellent activity, with compound 24c being the most promising one, since it displayed consistently low nanomolar activity in the various assays.

Effect of substituent in pyridine-2-carbaldehydes on their heterocyclization to 1,2,4-triazines and 1,2,4-triazine 4-oxides

A series of substituted pyridine-2-carbaldehydes were brought into heterocyclization with isonitrosoacetophenone hydrazones, followed by aromatization by the action of oxidants or by dehydration in boiling acetic acid. As a result, substituted 3-(pyridin-2-yl)-1,2,4-triazines or 3-(pyridin-2-yl)-1,2,4-triazine 4-oxides were formed. 6-Formylpyridine-2-carbonitrile failed to undergo heterocyclization, 6-methylpyridine-2-carbaldehyde and methyl 6-formylpyridine-3-carboxylate can be converted to both 1,2,4-triazine and 1,2,4-triazine 4-oxide derivative, and only 1,2,4-triazine 4 oxides were obtained from 6-bromopyridine-2-carbaldehyde and 6-formyl-3-phenylpyridine-2-carbonitrile. Convenient procedures were proposed for the synthesis of some initial pyridinecarbaldehydes.

NOVEL NITROGENOUS COMPOUND AND USE THEREOF

A novel nitrogen-containing compound effective against diseases such as HIV viral infectious diseases, rheumatism, and cancerous metastasis. It is a nitrogen-containing compound represented by the following general formula (1). In the formula, A typically represents a group represented by the formula (2) (A1 is hydrogen or an optionally substituted, mono- or polycyclic, heteroaromatic or aromatic ring; G1 is a single bond or a hydrocarbon group represented by the following formula (3) wherein R1, R2, and R3 may be optionally substituted hydrocarbon groups); W is an optionally substituted hydrocarbon group or heterocyclic ring; x is -C(=O)NH-; y is -C(=O)-; and D1 is hydrogen atom, alkyl having a polycyclic aromatic ring, di (substituted alkyl)amine, or alicyclic amine.