(6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξ_a)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

• Chemical Name: (6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξ_a)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS No.: 57617-47-7
• Molecular Formula: C₃₀H₂₆N₂O₄S
• Molecular Weight: 510.613
• Mol file: 57617-47-7.mol

Synonyms:

Chemical Property of (6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξ_a)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξ_a)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 2 articles about (6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξ_a)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lithium methanolate (865-34-9) + (6R)-7t-((Ξ)-2-chloro-2-phenyl-acetylamino)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (57617-49-9) → (6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξa)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (57617-47-7)

Guidance literature:

Multistep reaction; (i) PCl₅, (ii) /BRN= 3552389/, MeOH, THF, (iii) AcOH;

DOI:10.1016/S0040-4039(00)78047-6

Reference yield:

→ (6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξa)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (57617-47-7)

Guidance literature:

Entsprech. Ester, PCl5/Chinolin;

Reference yield:

(6R)-7c-methoxy-3-methyl-8-oxo-7t-(Ξa)-styrylideneamino-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (57617-47-7) → (6R)-7c-methoxy-3-methyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (57617-50-2)

Guidance literature:

Multistep reaction; (i) CF₃CO₂H, (ii) H₂O;

DOI:10.1016/S0040-4039(00)78047-6

upstream raw materials:

lithium methanolate

(6R)-7t-((Ξ)-2-chloro-2-phenyl-acetylamino)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Downstream raw materials:

(6R)-7c-methoxy-3-methyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid