Olopatadine

Base Information

Chemical Name:Olopatadine
CAS No.:113806-05-6
Molecular Formula:C21H23NO3
Molecular Weight:337.419
Hs Code.:
Mol file:113806-05-6.mol

Synonyms:Dibenz[b,e]oxepin-2-aceticacid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (Z)-;11-[(Z)-3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-aceticacid;Opatanol;Pataday;Patanol;

Suppliers and Price of Olopatadine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Olopatadine
50mg
$ 195.00

TRC
Olopatadine
250mg
$ 780.00

Matrix Scientific
Olopatadine 95+%
1g
$ 5940.00

Crysdot
(Z)-2-(11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticacid 97%
25mg
$ 320.00

AvaChem
Olopatadine
1g
$ 590.00

AvaChem
Olopatadine
100mg
$ 169.00

AvaChem
Olopatadine
25mg
$ 89.00

Alichem
(Z)-2-(11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticacid
1g
$ 920.82

Total 104 raw suppliers

Chemical Property of Olopatadine

Chemical Property:

Appearance/Colour:white or off-white crystalline powder
Melting Point:188-189.5°
Boiling Point:523 °C at 760 mmHg
Flash Point:270.1 °C
PSA：49.77000
Density:1.221 g/cm³
LogP:3.58950
Storage Temp.:Amber Vial, Refrigerator
Solubility.:Chloroform (Slightly, Heated), DMSO (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Olopatadine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Description Olopatadine belongs to a kind of antihistamine reagent. It is a relatively selective H1-receptor antagonist and can inhibit the histamine release process from the mast cell, subsequently leading to temporary relief on the negative symptoms associated with histamine. It is devoid of effects on alpha-adrenergic, dopamine and muscarinic type I and II receptors. Its 0.1% solution can be used for topical administration to the eyes. It is indicated for the treatment of itching associated with allergic conjunctivitis.
Uses Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic. Anti-allergic.
Therapeutic Function Antiallergic

Technology Process of Olopatadine

There total 24 articles about Olopatadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.09%

: 951006-73-8
(Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide

: 113806-05-6
olopatadine

Guidance literature:: With sodium hydroxide; In water; at 5 - 25 ℃; for 20 - 21.0833h; pH=6.8 - 7.2; Product distribution / selectivity;

Reference yield: 92.0%

: 113806-01-2
(Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester

: 113806-05-6
olopatadine

Guidance literature:: (Z)-11-<3-(dimethylamino)propylidene>-6,11-dihydrodibenzoxepin-2-acetic acid methyl ester; With methanol; sodium hydroxide; water; at 20 ℃; for 5h;

With hydrogenchloride; In methanol; water;

In methanol; water;

Reference yield: 81.2%

: 55453-87-7
isoxepac

: 53929-74-1
N,N-dimethyl-3-bromopropylamine

: 113806-05-6
olopatadine

Guidance literature:: N,N-dimethyl-3-bromopropylamine; With zinc dibromide; In tetrahydrofuran; at 10 - 20 ℃; for 0.166667h; Inert atmosphere;

With naphthalene; lithium; In tetrahydrofuran; at 65 - 70 ℃; Inert atmosphere;

isoxepac; In tetrahydrofuran; at 0 - 25 ℃; for 16.5h; Reagent/catalyst; Temperature;