Technology Process of 1H-Indole,
1-ethyl-6-methoxy-7-(methoxymethoxy)-2-(4-methoxyphenyl)-3-methyl-
There total 6 articles about 1H-Indole,
1-ethyl-6-methoxy-7-(methoxymethoxy)-2-(4-methoxyphenyl)-3-methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi, 2.) diphenylphosphoryl azide, 3.) sodium bis(2-methoxyethoxy)aluminum hydride
2: 81 percent / pyridine / tetrahydrofuran / 0.5 h / Ambient temperature
3: 39 percent / n-BuLi / tetrahydrofuran; hexane / 12 h / Ambient temperature
4: POCl3 / 1 h / Ambient temperature
5: LiAlH4 / tetrahydrofuran / 2 h / Heating
6: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min
With
pyridine; lithium aluminium tetrahydride; n-butyllithium; diphenylphosphoranyl azide; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; trichlorophosphate;
In
tetrahydrofuran; hexane;
DOI:10.1016/0223-5234(96)89134-3
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / pyridine / tetrahydrofuran / 0.5 h / Ambient temperature
2: 39 percent / n-BuLi / tetrahydrofuran; hexane / 12 h / Ambient temperature
3: POCl3 / 1 h / Ambient temperature
4: LiAlH4 / tetrahydrofuran / 2 h / Heating
5: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min
With
pyridine; lithium aluminium tetrahydride; n-butyllithium; sodium hydride; trichlorophosphate;
In
tetrahydrofuran; hexane;
DOI:10.1016/0223-5234(96)89134-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1: POCl3 / 1 h / Ambient temperature
2: LiAlH4 / tetrahydrofuran / 2 h / Heating
3: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, RT, 30 min
With
lithium aluminium tetrahydride; sodium hydride; trichlorophosphate;
In
tetrahydrofuran;
DOI:10.1016/0223-5234(96)89134-3
