1H-Pyrazole-4-carboxylic acid, 3-(1-methylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-4-carboxylic acid, 3-(1-methylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester
CAS No.:177846-40-1
Molecular Formula:C45H44N6O2
Molecular Weight:700.883
Hs Code.:

1H-Pyrazole-4-carboxylic acid,
3-(1-methylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'
-biphenyl]-4-yl]methyl]-, ethyl ester

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Chemical Property of 1H-Pyrazole-4-carboxylic acid, 3-(1-methylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester

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Technology Process of 1H-Pyrazole-4-carboxylic acid, 3-(1-methylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester

There total 6 articles about 1H-Pyrazole-4-carboxylic acid, 3-(1-methylethyl)-1-propyl-5-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

aqueous Na₂ CO₃: aqueous Na₂ CO₃

: 121-43-7,63156-11-6
Trimethyl borate

: 20485-44-3
2,3-dimethyl-2,3-diaminobutane

: 87268-78-8
2-trityl-5-phenyl-2H-tetrazole

: 177846-40-1
Ethyl 3-isopropyl-1-propyl-5-[[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-4-carboxylate

Guidance literature:: With sec.-butyllithium; Pd(PPh₃)4; In tetrahydrofuran; benzene;

Reference yield:

: 143722-25-2
2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid

: 177846-38-7
5-(4-Bromo-benzyl)-3-isopropyl-1-propyl-1H-pyrazole-4-carboxylic acid ethyl ester

: 177846-40-1
Ethyl 3-isopropyl-1-propyl-5-[[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-4-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In 1,2-dimethoxyethane; at 100 ℃;
DOI:10.1021/jm9604383

Reference yield:

: 37859-24-8
2-(4-bromophenyl)acetyl chloride

: 177846-40-1
Ethyl 3-isopropyl-1-propyl-5-[[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Na / 1.) Et₂O, RT, overnight, 2.) Et₂O, a) RT, overnight, b) reflux, 1 h

2: NH₂NH₂*H₂O, AcOH / 18 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 0 deg C, 10 min, 2.) DMF, 20 deg C, 18 h

4: CsF, Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium; sodium hydride; hydrazine hydrate; acetic acid; cesium fluoride; In 1,2-dimethoxyethane;
DOI:10.1021/jm9604383