1H-Pyrido[4,3-b]indole, 6-fluoro-2,3,4,5-tetrahydro-

Base Information

• Chemical Name: 1H-Pyrido[4,3-b]indole, 6-fluoro-2,3,4,5-tetrahydro-
• CAS No.: 177858-77-4
• Molecular Formula: C₁₁H₁₁FN₂
• Molecular Weight: 190.22
• Hs Code.: 2933990090
• Mol file: 177858-77-4.mol

Synonyms:6-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole;6-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride salt;

Chemical Property of 1H-Pyrido[4,3-b]indole, 6-fluoro-2,3,4,5-tetrahydro-

Chemical Property:

• Melting Point: 214～216℃
• PSA: 27.82000
• LogP: 3.08350

Purity/Quality:

99% ^*data from raw suppliers

6-FLUORO-1,2,3,4-TETRAHYDROPYRIDO[4,3-B]INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrido[4,3-b]indole, 6-fluoro-2,3,4,5-tetrahydro-

There total 2 articles about 1H-Pyrido[4,3-b]indole, 6-fluoro-2,3,4,5-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2-fluorophenyl)hydrazine hydrochloride (2924-15-4) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 6-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (177858-77-4)

Guidance literature:

With sulfuric acid; at 0 - 100 ℃; for 4h;

Reference yield:

4-piperidone hydrochloride (41979-39-9) + (2-fluorophenyl)hydrazine hydrochloride (2924-15-4) → 6-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (177858-77-4)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 80 ℃;

DOI:10.1021/jm3007257

Reference yield:

trans-1,2-cyclohexanedicarboxylic anhydride (85-42-7,13149-00-3,14166-21-3,31982-85-1,71749-03-6,97233-90-4) + 6-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (177858-77-4) → C19H21FN2O3

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm3007257

upstream raw materials:

4-piperidone hydrochloride

(2-fluorophenyl)hydrazine hydrochloride

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

(1R,2R)-N-(1-cyanocyclopropyl)-2-[(6-fluoro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)carbonyl]cyclohexanecarboxamide