1-(3-METHOXYPHENYL)-2-THIOUREA

Base Information

• Chemical Name: 1-(3-METHOXYPHENYL)-2-THIOUREA
• CAS No.: 37014-08-7
• Molecular Formula: C8H10N2OS
• Molecular Weight: 182.246
• Hs Code.: 2930909090
• European Community (EC) Number: 674-117-6
• NSC Number: 130357
• DSSTox Substance ID: DTXSID10958189
• Nikkaji Number: J2.339.342E
• Mol file: 37014-08-7.mol

Synonyms:(3-Methoxyphenyl)thiourea;1-(m-Methoxyphenyl)thiourea;3-Thioureidoanisole;N-(3-Methoxyphenyl)thiourea;N-(m-Methoxyphenyl)thiourea;NSC 130357;

Chemical Property of 1-(3-METHOXYPHENYL)-2-THIOUREA

Chemical Property:

• Vapor Pressure: 0.000778mmHg at 25°C
• Melting Point: 160 °C
• Refractive Index: 1.677
• Boiling Point: 306.3 °C at 760 mmHg
• Flash Point: 139 °C
• PSA: 79.37000
• Density: 1.287 g/cm³
• LogP: 2.12400
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 182.05138412
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Methoxyphenyl)-2-thiourea ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)NC(=S)N

Technology Process of 1-(3-METHOXYPHENYL)-2-THIOUREA

There total 13 articles about 1-(3-METHOXYPHENYL)-2-THIOUREA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxyphenyl isothiocyanate (3125-64-2) → 3-methoxyphenylthiourea (37014-08-7)

Guidance literature:

With ammonia; In dichloromethane; at 0 ℃; for 3.5h;

DOI:10.1016/S0968-0896(03)00451-6

Reference yield: 75.0%

m-Anisidine (536-90-3,918666-97-4) + Benzoyl isothiocyanate (532-55-8) → 3-methoxyphenylthiourea (37014-08-7)

Guidance literature:

m-Anisidine; Benzoyl isothiocyanate; In dichloromethane; at 20 ℃; for 12h;

With sodium hydroxide; In tetrahydrofuran; water; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.6b01521

Reference yield: 18.0%

ammonium thiocyanate + m-Anisidine (536-90-3,918666-97-4) → 3-methoxyphenylthiourea (37014-08-7)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 16h;

DOI:10.1021/jm901457w

upstream raw materials:

potassium thioacyanate

m-Anisidine

3-methoxyphenyl isothiocyanate

m-anisidine hydrochloride

Downstream raw materials:

2-(3-methoxyphenylamino)thiazol-4-one

2-amino-5-methoxybenzothiazole

(4-benzothiazol-2-yl-thiazol-2-yl)-(3-methoxy-phenyl)-amine

[2'-(4-chloro-phenyl)-4'-methyl-[4,5']bithiazolyl-2-yl]-(3-methoxy-phenyl)-amine