(Phenylseleno)acetic acid

Base Information

• Chemical Name: (Phenylseleno)acetic acid
• CAS No.: 17893-46-8
• Molecular Formula: C8H8O2Se
• Molecular Weight: 215.11
• DSSTox Substance ID: DTXSID90901714
• Nikkaji Number: J1.468.206F
• Mol file: 17893-46-8.mol

Synonyms:NoName_854;2-phenylselenoacetic acid;(Phenylseleno)acetic acid;SCHEMBL2875192;DTXSID90901714

Chemical Property of (Phenylseleno)acetic acid

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 215.96895
• Heavy Atom Count: 11
• Complexity: 130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)[Se]CC(=O)O

Technology Process of (Phenylseleno)acetic acid

There total 19 articles about (Phenylseleno)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-(phenylselanyl)acetate (51364-94-4) → 2-(phenylselanyl)acetic acid (17893-46-8)

Guidance literature:

With ethanol; potassium hydroxide; at 0 ℃; for 1h;

DOI:10.1002/anie.201400617

Reference yield: 95.0%

diphenyl diselenide (1666-13-3) + chloroacetic acid (79-11-8) → 2-(phenylselanyl)acetic acid (17893-46-8)

Guidance literature:

With disodium hydrogenphosphate; zinc; In water; acetonitrile; for 1h;

DOI:10.1016/S0040-4039(01)00820-6

Reference yield: 89.0%

diphenyl diselenide (1666-13-3) + bromoacetic acid (79-08-3) → 2-(phenylselanyl)acetic acid (17893-46-8)

Guidance literature:

diphenyl diselenide; With sodium tetrahydroborate; In ethanol; Inert atmosphere; Cooling with ice;

bromoacetic acid; In ethanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b01320

upstream raw materials:

Benzeneselenol

chloroacetic acid

diethyl ether

ethyl phenyl selenide

Downstream raw materials:

methyl (2RS,4R,5S,11R)-11-(tert-butyldimethylsilyloxy)-4,5-dihydroxy-2-(phenylseleno)dodecanoate

4-Hydroxy-4-phenyl-2-phenylselanyl-butyric acid

5-phenylthiomethyl-3-phenylselenotetrahydrofuran-2-one

Tris-(2-hydroxyethyl)ammonium phenylselenoacetate