5-(3-AMino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate)

Base Information

Chemical Name:5-(3-AMino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate)
CAS No.:179101-49-6
Molecular Formula:C12H18N3O14P3
Molecular Weight:521.208
Hs Code.:
Mol file:179101-49-6.mol

Synonyms:5-[3-aminoprop-1-ynyl]-2'-deoxyuridin-5'-triphosphate;5-aminopropargyl-2'-deoxyuridine-5'-triphosphate;5-(3-Amino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate);5-(3''-aminopropynyl)-2'-deoxyuridine 5'-triphosphate;Uridine 5'-(tetrahydrogen triphosphate),5-(3-amino-1-propynyl)-2'-deoxy-;

Suppliers and Price of 5-(3-AMino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(3-Amino-1-propyn-1-yl)-2''-deoxyuridine5''-(TetrahydrogenTriphosphate)
1mg
$ 160.00

Medical Isotopes, Inc.
5-(3-Amino-1-propyn-1-yl)-2??-deoxyuridine5??-(TetrahydrogenTriphosphate)
10 mg
$ 2200.00

Total 15 raw suppliers

Chemical Property of 5-(3-AMino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate)

Chemical Property:

PSA：299.59000
LogP:-1.46120
Solubility.:Water

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(3-Amino-1-propyn-1-yl)-2''-deoxyuridine5''-(TetrahydrogenTriphosphate) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5-(3-Amino-1-propyn-1-yl)-2''-deoxyuridine 5''-(Tetrahydrogen Triphosphate) is an intermediate in the synthesis of Texas Red-5-dUTP (T320100), a fluorescence-labelled nucleotide analog. Texas Red-5-dUTP is used diagnostically for detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.

Technology Process of 5-(3-AMino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate)

There total 9 articles about 5-(3-AMino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115899-40-6
2,2,2-trifluoro-N-(3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-yn-1-yl)acetamide

: 179101-49-6
5-(3-amino-1-propynyl)-2'-deoxyuridine 5'-triphosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethyl-1,8-naphthalenediamine; POCl₃; PO(OMe)3 / 3 h / 0 °C

1.2: (nBu₃NH)2H₂P₂O₇; nBu₃N / dimethylformamide / 0.17 h / 0 °C

1.3: aq. triethylammonium bicarbonate / dimethylformamide

2.1: aq. NH₃ / 3 h

With trimethyl phosphite; ammonium hydroxide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate;
DOI:10.1021/ja051725b

Reference yield:

: 179101-52-1
C₁₄H₁₇F₃N₃O₁₅P₃

: 179101-49-6
5-(3-amino-1-propynyl)-2'-deoxyuridine 5'-triphosphate

Guidance literature:: With ammonium hydroxide; for 3h;
DOI:10.1021/ja051725b

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 179101-49-6
5-(3-amino-1-propynyl)-2'-deoxyuridine 5'-triphosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / CuI; triethylamine; Pd(PPh₃)4 / dimethylformamide / 3.5 h / 20 °C

2.1: N,N,N',N'-tetramethyl-1,8-naphthalenediamine; POCl₃; PO(OMe)3 / 3 h / 0 °C

2.2: (nBu₃NH)2H₂P₂O₇; nBu₃N / dimethylformamide / 0.17 h / 0 °C

2.3: aq. triethylammonium bicarbonate / dimethylformamide

3.1: aq. NH₃ / 3 h

With trimethyl phosphite; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; 1.1: Sonogashira coupling;
DOI:10.1021/ja051725b