115899-40-6 Usage
Description
TFA-ap-dU, or 2''-Deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]uridine, is an intermediate compound utilized in the synthesis of fluorescent labeling compounds for cyclooctyne-modified deoxyuridine triphosphates in DNA. This molecule plays a crucial role in the development of advanced DNA imaging and detection techniques.
Uses
Used in Biotechnology and Molecular Biology:
TFA-ap-dU is used as an intermediate compound for the synthesis of fluorescent labeling agents in DNA research. Its application is primarily focused on enhancing the visualization and detection of specific DNA sequences, which is essential for various molecular biology and biotechnology applications.
Used in Diagnostics:
In the diagnostics industry, TFA-ap-dU is used as a component in the development of diagnostic tools that rely on DNA sequencing and analysis. The fluorescent labeling compounds synthesized using TFA-ap-dU can help improve the accuracy and efficiency of disease detection and monitoring.
Used in Research and Development:
TFA-ap-dU is employed as a key intermediate in the synthesis of novel fluorescent probes for research and development purposes. These probes can be used to study various biological processes, such as DNA replication, transcription, and repair, as well as to develop new therapeutic strategies targeting DNA-related diseases.
Used in Drug Discovery:
In the pharmaceutical industry, TFA-ap-dU can be utilized in the development of new drugs that target DNA or DNA-related processes. The fluorescent labeling compounds derived from TFA-ap-dU can aid in the identification and characterization of potential drug candidates, contributing to the advancement of drug discovery efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 115899-40-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,8,9 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 115899-40:
(8*1)+(7*1)+(6*5)+(5*8)+(4*9)+(3*9)+(2*4)+(1*0)=156
156 % 10 = 6
So 115899-40-6 is a valid CAS Registry Number.
115899-40-6Relevant articles and documents
Synthesis and enzymatic incorporation of modified deoxyuridine triphosphates
Borsenberger, Vinciane,Kukwikila, Mikiembo,Howorka, Stefan
, p. 3826 - 3835 (2009)
We describe the synthesis of 2′-deoxyuridine-5′-triphosphate derivatives bearing linkers of varying length, bulk and flexibility, at position 5 of the pyrimidine base. Nucleotide analogues with terminal functional groups are of interest due to their appli
MODIFIED NUCLEOTIDES AND USES THEREOF
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Paragraph 0404, (2021/10/30)
Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF
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Paragraph 0778, (2020/07/26)
Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
DISULFIDE-LINKED REVERSIBLE TERMINATORS
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Paragraph 00123, (2016/11/28)
The present disclosure provides methods of sequencing polynucleotides and compounds, compositions useful for sequencing of polynucleotides. The chemical compounds include nucleotides and their analogs which possess a sugar moiety comprising a cleavable chemical group capping the 3'-OH group and a base that is attached to a detectable label through a cleavable linker comprising a disulfide bond. In addition, both the disulfide bond and the cleavable chemical group are cleavable by a chemical reagent. Furthermore, after the disulfide bond is cleaved by the chemical reagent, there is no free thiol group linked to the base of the nucleotides.
