4-(2-fluorobenzyloxy)-3-chlorobenzenaMine

Base Information

• Chemical Name: 4-(2-fluorobenzyloxy)-3-chlorobenzenaMine
• CAS No.: 179246-45-8
• Molecular Formula: C13H11ClFNO
• Molecular Weight: 251.68400
• Mol file: 179246-45-8.mol

Synonyms:

Chemical Property of 4-(2-fluorobenzyloxy)-3-chlorobenzenaMine

Chemical Property:

• Boiling Point: 390.5±32.0 °C(Predicted)
• PKA: 3.95±0.10(Predicted)
• PSA: 35.25000
• Density: 1.306±0.06 g/cm3(Predicted)
• LogP: 4.22150

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-4-[(2-fluorophenyl)methoxy]aniline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-fluorobenzyloxy)-3-chlorobenzenaMine

There total 5 articles about 4-(2-fluorobenzyloxy)-3-chlorobenzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

2-chloro-1-[(2-fluorobenzyl)oxy]-4-nitrobenzene (179246-44-7) → 4-(2-fluorobenzyloxy)-3-chlorobenzenamine (179246-45-8)

Guidance literature:

With iron; ammonium chloride; In methanol; ethanol; water; at 68 ℃; for 2h; Inert atmosphere;

Reference yield: 37.0%

→ 4-(2-fluorobenzyloxy)-3-chlorobenzenamine (179246-45-8)

Guidance literature:

With ammonium chloride; zinc; In methanol; water; at 50 ℃; for 6h;

Reference yield:

2-chloro-4-nitrophenol (619-08-9) → 4-(2-fluorobenzyloxy)-3-chlorobenzenamine (179246-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 12 h / 25 - 50 °C

2: zinc; ammonium chloride / water; methanol / 6 h / 25 - 50 °C

With potassium carbonate; ammonium chloride; zinc; In methanol; water; acetonitrile;

DOI:10.1021/jm400349k

upstream raw materials:

o-fluorobenzyl bromide

2-chloro-4-nitrophenol

2-chloro-1-[(2-fluorobenzyl)oxy]-4-nitrobenzene

Downstream raw materials:

5-[4-({3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}amino)quinazoline-6-yl]furan-2-carbaldehyde

N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine