1-Methoxy-4-(2-methylidenecyclopropyl)benzene

Base Information

• Chemical Name: 1-Methoxy-4-(2-methylidenecyclopropyl)benzene
• CAS No.: 17953-96-7
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• DSSTox Substance ID: DTXSID60578952
• Nikkaji Number: J1.533.980B
• Mol file: 17953-96-7.mol

Synonyms:17953-96-7;1-Methoxy-4-(2-methylidenecyclopropyl)benzene;DTXSID60578952

Chemical Property of 1-Methoxy-4-(2-methylidenecyclopropyl)benzene

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 160.088815002
• Heavy Atom Count: 12
• Complexity: 177

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2CC2=C

Technology Process of 1-Methoxy-4-(2-methylidenecyclopropyl)benzene

There total 4 articles about 1-Methoxy-4-(2-methylidenecyclopropyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Methoxystyrene (637-69-4,24936-44-5) → 1-(p-methoxyphenyl)-2-methylenecyclopropane (17953-96-7)

Guidance literature:

Multi-step reaction with 3 steps

1: benzyltriethylammonium chloride; aq. NaOH

2: n-butyllithium / tetrahydrofuran

3: potassium tert-butoxide; DMSO

With sodium hydroxide; n-butyllithium; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; dimethyl sulfoxide; In tetrahydrofuran;

DOI:10.1021/ja0277982

Reference yield:

1,1-dibromo-2-(4-methoxyphenyl)cyclopropane (65038-31-5) → 1-(p-methoxyphenyl)-2-methylenecyclopropane (17953-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran

2: potassium tert-butoxide; DMSO

With n-butyllithium; potassium tert-butylate; dimethyl sulfoxide; In tetrahydrofuran;

DOI:10.1021/ja0277982

Reference yield:

trans-1-bromo-2-(4-methoxyphenyl)-1-methylcyclopropane → 1-(p-methoxyphenyl)-2-methylenecyclopropane (17953-96-7)

Guidance literature:

With potassium tert-butylate; dimethyl sulfoxide;

DOI:10.1021/ja0277982

upstream raw materials:

1,2-propanediene

p-methoxyphenyldiazomethane

4-Methoxystyrene

1,1-dibromo-2-(4-methoxyphenyl)cyclopropane

Downstream raw materials:

RhCl(P(C₆H₅)3)2(C₁₁H₁₂O)

1-methylene-2-phenylcyclopropane

2-[(4-methoxyphenyl)-(tributylsilyl)-methyl]-1,4-pentadiene

[2-(4-methoxyphenyl)cyclopropyl]acetaldehyde