1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE

Base Information

• Chemical Name: 1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE
• CAS No.: 179897-92-8
• Molecular Formula: C7H5BrFNO3
• Molecular Weight: 250.024
• Hs Code.: 2909309090
• Mol file: 179897-92-8.mol

Synonyms:1-Bromo-5-fluoro-2-methoxy-3-nitrobenzene;

Chemical Property of 1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE

Chemical Property:

• Boiling Point: 307.7±37.0 °C(Predicted)
• PSA: 55.05000
• Density: 1.716±0.06 g/cm3(Predicted)
• LogP: 3.02820
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4-fluoro-6-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 1-Bromo-5-fluoro-2-methoxy-3-nitrobenzene, a specific chemical compound, finds application in diverse fields, each with distinct roles. In the realm of pharmaceuticals, it serves as a valuable intermediate in the synthesis of complex molecules for drug development, contributing to the creation of potential therapeutic agents. In organic chemistry, this compound acts as a versatile building block, facilitating the construction of intricate molecular structures and enabling the advancement of chemical research. Furthermore, in agrochemicals, it can play a role in the formulation of pesticides, contributing to pest management and crop protection. The compound's varied applications in pharmaceuticals, chemistry, and agriculture highlight its significance in driving innovation, scientific exploration, and practical solutions across these crucial domains.

Technology Process of 1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE

There total 2 articles about 1-BROMO-5-FLUORO-2-METHOXY-3-NITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

2-bromo-4-fluoro-6-nitrophenol (320-75-2) + methyl iodide (74-88-4) → 1-bromo-5-fluoro-2-(methyloxy)-3-nitrobenzene (179897-92-8)

Guidance literature:

With potassium carbonate; In acetone; at 80 ℃; for 22h;

Reference yield:

2-bromo-4-fluoro-1-methoxybenzene (452-08-4) → 1-bromo-5-fluoro-2-(methyloxy)-3-nitrobenzene (179897-92-8)

Guidance literature:

With sulfuric acid; nitric acid; at -10 ℃;

Reference yield: 41.7%

1-bromo-5-fluoro-2-(methyloxy)-3-nitrobenzene (179897-92-8) + 3-Carboxyphenylboronic acid (25487-66-5) → 5'-fluoro-2'-methoxy-3'-nitro-biphenyl-3-carboxylic acid (1176778-03-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 24h;

upstream raw materials:

2-bromo-4-fluoro-6-nitrophenol

methyl iodide

2-bromo-4-fluoro-1-methoxybenzene

Downstream raw materials:

6-(5-Fluoro-2-methoxy-3-nitrophenyl)-1,2-dihydro-2,2,4-trimethylquinoline

5'-fluoro-2'-methoxy-3'-nitro-biphenyl-3-carboxylic acid

ethyl 4-[5-fluoro-2-(methyloxy)-3-nitrophenyl]butanoate

ethyl 4-[3-amino-5-fluoro-2-(methyloxy)phenyl]butanoate

Refernces

• 1、 -. "PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS". Page/Page column 31. . Retrieved 2011/10/10.
• 2、 -. "5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS". Page/Page column 83. . Retrieved 2011/01/12.